正天丸对多巴胺、硝酸甘油诱导的偏头痛大鼠模型脑干神经递质影响  

Effects of Zhengtian Pill on brain stem neurotransmitters of migraine rat model induced by Dopamine and Nitroglycerin

作　　者：李涛[1] 范吉平[2] 曹克刚[3] 徐立[4] 宋文婷[4] 

机构地区：[1]中国中医科学院广安门医院,北京100053 [2]中国中医科学院,北京100700 [3]北京中医药大学东直门医院,北京100700 [4]中国中医科学院西苑医院,北京100091

出　　处：《中华中医药杂志》2014年第2期444-446,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(No.30600828)~~

摘　　要：目的:观察正天丸对多巴胺、硝酸甘油诱导的偏头痛大鼠模型行为学及脑干神经递质影响。方法:采用腹部皮下先注射多巴胺,后注射硝酸甘油复制偏头痛大鼠模型,以盐酸氟桂利嗪为对照药,观察正天丸对偏头痛大鼠行为学及脑干神经递质含量影响。结果:正天丸能增加偏头痛大鼠各时间段爬笼和挠头次数,但与模型组比较,无统计学差异;正天丸能提高大鼠脑干5-羟色胺(5-HT)含量(P<0.05),而脑干去甲肾上腺素(NE)、多巴胺(DA)、高香草酸(HVA)及3,4-二羟基苯乙酸(DOPAC)含量与模型组比较,无统计学差异。结论:正天丸对偏头痛大鼠模型行为学表现有一定改善作用,并可提高脑干5-HT水平,提示该药具有良好的偏头痛保护作用。Objective： To study the effects of Zhengtian Pill on the behavioristics and neurotransmitter contents in brain stem in migraine model induced by Dopamine and Nitroglycerin. Methods： Successively intrapefitoneal injection of Dopamine and Nitroglycerin induced rat migraine model. Flunarizine as control drug, observed the behavioristics and neurotransmitter contents of Zhengtian Pill on migraine. Results： Zhengtian Pill could improve the frequency of climbing cages and scratching heads of migraine rats, showing no significant difference compared with model group; Zhengtian Pill enhanced 5-HT contents in rat brain stems （P〈0.05）. The comparison with model group for the contents of NE, DA, HVA and DOPAC showed no significant difference. Conclusion： Zhengtian Pill can improve behavioristics of migraine rat model, and up-regulate the level of 5-HT, indicating its good effect on relieving migraine.

关 键 词：偏头痛 正天丸 行为学 神经递质 多巴胺 硝酸甘油 

分 类 号：R285.5[医药卫生—中药学]