氧化苦参碱镇痛作用及其阿片受体非相关性  

Analgesic effect of oxymatrine and its non-correlation with opioid receptors

作　　者：吕晓强[1] 邓扬鸥[2] 杨丽[1] 侯平[3] 刘永刚[4] 

机构地区：[1]辽宁中医药大学基础医学院药理教研室,辽宁中医药大学省部共建中医脏象理论及应用教育部重点实验室,沈阳110847 [2]中国医科大学附属第一医院,沈阳110001 [3]辽宁中医药大学附属医院,沈阳110032 [4]武警广东省总队医院,广州510507

出　　处：《中华中医药杂志》2014年第2期564-567,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金(No.81102901);教育部留学回国人员科研启动基金(No.教外司留[2012]940号);辽宁省自然科学基金(No.201102151);沈阳市科技计划项目(No.F11-264-1-71)~~

摘　　要：目的:探讨氧化苦参碱(OMT)在不同的疼痛模型中的镇痛效果。方法:建立小鼠肿瘤转移疼痛模型、神经性疼痛模型、化学刺激性疼痛模型、物理热刺激疼痛模型。采用up and down方法测足底机械缩足反应阈值(MWT)、观察扭体次数及舔后足现象,利用纳洛酮考察OMT镇痛作用与阿片受体的相关性。结果:OMT能够显著提高肿瘤转移疼痛模型和神经性疼痛模型中小鼠坐骨神经损伤后的机械缩足反应阈值(P<0.05,P<0.01),减少醋酸所致的小鼠扭体次数(P<0.01)及提高热刺激引起的痛阈(P<0.01)。此镇痛作用不能被纳洛酮所拮抗。结论:OMT对肿瘤转移性、神经病理性、化学性及物理刺激性疼痛均有抑制作用,此作用与阿片受体激动无关。Objective： To explore the analgesic effect of oxymatrine （OMT） in different models of pain. Methods： Tumor metastasis model of pain, neuropathic pain model, chemical irritation pain model and physical irritation pain model were established on mice. Through up and down method, hind paw plantar mechanical response threshold （MWT） was measured. The writhing and licking hind phenomena were observed. Opioid receptor antagonist naloxone was used to explore relation between analgesia of oxymatrine and activation of opioid receptors. Results： Oxymatrine significantly improved hind paw mechanical response thresholds （P〈0.05, P〈0.01） in both tumor metastasis model and neuropathic pain model, reduced the acetic acid-induced writhing times （P〈0.01） and improved pain threshold （P〈0.01） induced by thermal stimulation. This analgesic effect was not antagonized by Naloxone. Conclusion： Oxymatrine can suppress tumor metastasis-induced, neuropathic, chemical and physical pain without activation of opioid receptors.

关 键 词：氧化苦参碱 镇痛 疼痛模型 

分 类 号：R285.5[医药卫生—中药学]