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出 处:《辽宁中医药大学学报》2014年第2期88-90,共3页Journal of Liaoning University of Traditional Chinese Medicine
基 金:上海市卫生局中医药科研基金课题(2010J004A)
摘 要:目的 :研究中药结合雌孕激素对卵巢早衰模型大鼠血清AMH及VEGF的影响。方法 :建立免疫性卵巢早衰大鼠模型,造模成功者随机分为模型对照组、纯中药组、纯西药组和中西医结合组,每组各10只,另设空白对照组。空白及模型对照组予蒸馏水灌胃,纯中药组予育肾养血方汤剂灌胃,纯西药组予补佳乐及安宫黄体酮灌胃,中西医结合组予育肾养血方联合补佳乐及安宫黄体酮灌胃,14 d后用ELISA法检测大鼠血清AMH、VEGF水平。结果:中西医结合组大鼠血清AMH、VEGF均高于纯中药组或纯西药组(P<0.001)。结论 :中西医结合方案在提高卵巢早衰模型大鼠血清AMH、VEGF方面,疗效明显好于纯中药组或纯西药组。Objective: To study serum AMH and VEGF levels of premature ovarian failure model rats treated with traditional Chinese medicine combined with hormone. Methods: 40 rats, induced the models of autoimmune POF, were randomly divided into model group, TCM group, Western medicine group and combined TCM and Western medicine group, n=10. Rats in control group (n=10) and model group were treated with water. TCM group were treated with Yushen Yangxue Decoction. Western medicine group were treated with estrogen and progesterone. Combined TCM and Western medicine group were treated with Yushen Yangxue Decoction combined estrogen and progesterone. 14 days later, serum AMH and VEGF levels were tested by ELISA. Result: Serum AMH and VEGF levels of rats in combined TCM and Western medicine group were higher than those of TCM group or Western medicine group (P〈0.001 ). Conclusion: Proposal of combined TCM and Western medicine can improve serum AMH and VEGF levels of POF rats, and the efficacy was significantly better than TCM or Western medicine.
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