两药联合对铜绿假单胞菌生物膜作用研究进展  

Combined Effects of Two Drugs on Pseudomonas Aeruginosa Biofilms

作　　者：孙振新[1] 朱玲玲[1] 程惠娟[1] 

机构地区：[1]安徽中医药大学,安徽合肥230038

出　　处：《辽宁中医药大学学报》2014年第2期116-118,共3页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(81173629)

摘　　要：铜绿假单胞菌(PA)已成为院内感染的一个重要致病菌,其诱发疾病的特点呈慢性并反复急性发作,死亡率高。铜绿假单胞菌生物被膜(BF)的形成是其重要原因之一。细菌的生物膜能保护细菌抵御抗生素的作用形成耐药性,并能逃避机体免疫系统的攻击,从而造成慢性难治性感染。查阅近年有关文献表明,单种药物很难清除细菌生物被膜,药物联合在防治细菌生物膜感染方面具有独特的优势。该文就抗生素联合、中药联合抗生素抗铜绿假单胞菌生物膜的研究进行综述。Pseudomonas aeruginosa （PA ） has become an important pathogen of nosocomial infections. Antibiotic resistance has become the main deadly factor in infections, as bacteria can protect themselves by hiding in a self-constructed biofilm. It has been reported that the combination of two drugs was more effective in enhancing the efficiency of biofilm inhibition and removaL In this paper, the studies of two drugs which against pseudomonas aeruginosa biofilm were reviewed.

关 键 词：中药 抗生素 细菌生物膜 铜绿假单胞菌 

分 类 号：R378[医药卫生—病原生物学]