H_1受体阻滞剂在特发性肺间质纤维化所致呼吸衰竭中的应用探讨  

The Disscussion of H_1 Recepter Blokers' s Effect in Failure of Respiration Induced by Idiopathic Pulmonary Fibrosis

作　　者：张凯[1] 

机构地区：[1]三峡大学附属仁和医院,湖北宜昌443000

出　　处：《中国医学创新》2014年第3期25-27,共3页Medical Innovation of China

摘　　要：目的:观察H1受体阻滞剂治疗特发性肺间质纤维化所致的呼吸衰竭患者的疗效。方法:总结本院2011年1月-2012年5月60例弥漫性肺间质纤维化合并Ⅰ型呼吸衰竭患者,按照随机数字表法分为对照组和观察组30例,对照组予以抗感染,改善通气,平喘等治疗;观察组在上述治疗的基础上予以H1受体阻滞剂(非那根片)治疗,对比观察两组患者呼吸频率,心率、动脉血气分析、肺功能变化情况。结果:观察组在应用H1受体阻滞剂后呼吸频率、心率、SpO2、动脉血气分析、DLCO%pre(一氧化碳弥散量占预计值百分比)、患者自我喘息症状缓解程度改善方面均明显优于对照组,比较差异有统计学意义(P<0.05)。结论:H1受体阻滞剂能缓解呼吸衰竭所引起的症状,减少氧耗,改善血气水平。Objective：To investigate the effect of H1 recepter blokers in failure of respiration induced by idiopathic pulmonary fibrosis（IPF）. Method：Sixty patients with IPF were randomly divided into the control group and the observation group,with 30 patients in each group.Patients in the control group were given antibiotic,treatments on dysfunction of ventilation.Patients in the observation group were given H1 recepter blocker（Phenergan）, besides the same treatment of the control group.The clinical effects of the two groups were compared after 2 weeks after treatment.Result：The clinical symptoms and improvement in pulmonary diffusion of the observation group were better than those in the control group,such as breathing rate,heart rate, SpO2,arterial blood gas analysis,DLCO%pre,and the difference between the two groups were all statistically significant（P〈0.05）.Conclusion：The effect of H1 recepter blocker on IPF can relieve the symptoms of respiratory failure caused by,reduce the oxygen consumption,and improve the blood gas levels.

关 键 词：特发性肺间质纤维化 呼吸衰竭 H1受体拮抗剂 非那根 

分 类 号：R563.8[医药卫生—呼吸系统]