林蛙油治疗绝经后骨质疏松症的临床研究  

Clinical study of Rana temporaria oil in the treatment of postmenopausal osteoporosis

作　　者：王丹辉[1] 贲越[2] 韩梅[3] 

机构地区：[1]吉林省中医药科学院,吉林长春130021 [2]吉林省长春市中医院,吉林长春130021 [3]广东省广州市红十字会医院,广东广州510000

出　　处：《中医正骨》2014年第1期27-30,37,共5页The Journal of Traditional Chinese Orthopedics and Traumatology

基　　金：吉林省中医药管理局资助项目(2012-115);长春市科技计划科技项目(2012114)

摘　　要：目的:观察林蛙油治疗绝经后骨质疏松症的临床疗效,并探讨其作用机制。方法:将60例绝经后骨质疏松症患者随机分为治疗组和对照组,每组30例,治疗组采用口服林蛙油治疗,对照组采用口服仙灵骨葆胶囊治疗。治疗6个月后,观察2组患者治疗前后临床症状体征评分改变及骨密度、骨代谢指标变化情况。结果:①症状体征评分。治疗前2组患者症状体征评分比较,差异无统计学意义(t=1.781,P=0.113);治疗6个月后,2组患者症状体征评分均较治疗前降低[(17.67±3.67)分,(6.44±2.46)分,t=13.808,P=0.000;(20.22±2.17)分,(11.89±1.90)分,t=15.811,P=0.007],治疗组降低更明显[(11.23±2.44)分,(8.33±1.58)分,t=2.760,P=0.025]。②骨密度。治疗前和治疗6个月后,2组患者骨密度比较,组间差异均无统计学意义(t=0.824,P=0.425;t=0.767,P=0.457);治疗6个月后,2组患者骨密度与治疗前比较,差异均无统计学意义[(-2.37±0.84)g·cm-2,(-2.65±0.91)g·cm-2,t=0.811,P=0.432;(-2.19±0.83)g·cm-2,(-2.41±0.56)g·cm-2,t=0.727,P=0.479]。③骨代谢指标。治疗前2组患者骨碱性磷酸酶、雌二醇、白细胞介素-6、骨钙素血清含量比较,组间差异均无统计学意义(t=1.622,P=0.127;t=1.114,P=0.284;t=1.554,P=0.143;t=1.185,P=0.160)。治疗6个月后,2组患者血清骨碱性磷酸酶含量[(17.13±2.13)单位·L-1,(7.80±1.82)单位·L-1,t=12.594,P=0.000;(16.40±1.80)单位·L-1,(10.73±2.12)单位·L-1,t=8.324,P=0.000]、血清白细胞介素-6含量[(125.20±13.86)μg·L-1,(88.13±10.20)μg·L-1,t=5.795,P=0.000;(131.93±11.07)μg·L-1,(107.40±7.74)μg·L-1,t=9.648,P=0.000]、血清骨钙素含量[(6.19±0.96)ng·L-1,(3.54±1.12)ng·L-1,t=6.504,P=0.000;(5.80±0.56)ng·L-1,(5.15±0.51)ng·L-1,t=6.733,P=0.000]均较治疗前降低,治疗组降低更明显[(9.33±2.87)单位·L-1,(5.67±2.64)单位·L-1,t=7.416,P=0.000;(37.17±19.08)μg·L-1,(24.53±9.85)μg·L-1,t=2.253,P=0.041;(2.65±1.53)ng·L-1,(0.64±0.37)ng·L-1,t=4.820,P=0.000];2组患者血清�Objective：To observe the clinical effects of Rana temporaria oil on postmenopausal osteoporosis（PMOP） and to explore its mechanisms of action. Methods：Sixty patients with PMOP were randomly divided into treatment group and control group,30 cases in each group. The patients in treatment group were treated with Rana temporaria oil, while the others in control group were treated with XIANLING GUBAO capsules. The changes in clinical symptoms and signs scores, bone density and bone metabolism index were observed and compared between the 2 groups before and after 6-month treatment. Results：There were no statistical difference in the symptoms and signs scores be- tween the 2 groups before the treatment （t = 1.781, P = 0.113 ）. while the symptoms and signs scores decreased in both of the 2 groups after 6 - month treatment（ 17.67 ^-3.67 vs 6.44 ^- 2.46 points,t = 13. 808 ,P = 0. 000;20.22 ^- 2.17 vs 11.89 4-/- 1.90 points,t = 15.811,P = 0. 007）, and the scores decreased more significantly in the treatment group （11.23 ^-2.44 vs 8.33 ^- 1.58 points, t =2. 760 ,P = 0. 025 ）. There were no statistical difference in bone density between the 2 groups before the treatment and after 6 - month treat- ment（t = 0. 824 ,P = 0. 425;t = 0. 767 ,P = 0. 457 ）. There were no statistical difference in bone density between pre - and post-treatment （ -2.37 4,/-0.84 vs -2.65 ＋/-0.91 g/cm（2） ,t =0. 8ll ,P =0. 432; -2.19 ＋/-0.83 vs -2.41 ＋/-0.56 g/cm（2） ,t =0. 727 ,P = 0. 479 ）. There were no statistical difference between the 2 groups in the serum concentrations of bone alkaline phosphatase, estradiol, inter- leukin-6 and osteocalcin before the treatment（t = 1. 622,P =0. 127;t = 1. l14,P =0. 284;t = l. 554,P =0. 143;t = 1. 185,P =0. 160）. The serum concentrations of bone alkaline phosphatase（ 17.13 ＋/-2.13 vs 7.80 ＋/-1.82 units/L, t = 12. 594 ,P--0. 000;16.40 ＋/-1.80 vs 10.73 ＋/- 2.12 units/L, t = 8. 324, P = 0. 000）, interleukin-6 （ 125.20 4/- 13.86 vs 88.13 4/- 10.20 ~g/L, t = 5.

关 键 词：骨质疏松 绝经后 林蛙 仙灵骨葆胶囊 治疗 临床研究性 骨密度 碱性磷酸酶 骨钙素 雌二醇 白细胞介素6 

分 类 号：R259[医药卫生—中西医结合]