手性Salen-Cu(Ⅱ)和噁唑啉-Cu(Ⅱ)配合物催化2-苯基环己酮的不对称Baeyer-Villiger反应研究  

A Study of Asymmetric Baeyer-Villiger Reaction of 2-Phenylcyclohexanone Catalyzed by Chiral Salen-Cu(Ⅱ) and Oxazoline-Cu(Ⅱ) Complexes

作　　者：彭云贵[1] 冯小明[2] 王斌[1] 李智[1] 杨桂树[1] 蒋耀忠[1] 

机构地区：[1]中国科学院成都有机化学研究所不对称合成联合开放实验室,成都610041 [2]四川大学化学学院,成都610064

出　　处：《高等学校化学学报》2001年第2期223-227,共5页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金!(批准号 :2 9832 0 2 0 )资助

摘　　要：对一系列手性Salen和唑啉配体与中心金属Cu(Ⅱ )的配合物催化 2 苯基环己酮的不对称Baeyer Villiger反应进行了研究 ,设计和合成了新型手性配体Ⅲ ,Ⅳ ,Ⅴ ,对配合物Ⅴ Cu(Ⅱ )进行了单晶X射线衍射分析 .并考察了助氧化剂、溶剂等对反应活性和选择性的影响 .In this paper, we have studied the asymmetric Baeyer-Villiger reaction of 2-phenylcyclohexanone catalyzed by Cu(Ⅱ) complexes which derived from a series of chiral Salen and oxazoline ligands, as well as designed and synthesized the new chiral ligands Ⅲ, Ⅳ, Ⅴ. And the configuration of complex Ⅴ-Cu(Ⅱ) was determined by X-ray analysis. We also investigated the influence of co-oxidant, solvent, etc. on the reactivity and selectivity.

关 键 词：不对称催化 BAeYer-Villiger反应 2-苯基环已酮 

分 类 号：O624.42[理学—有机化学] O621.251[理学—化学]