钙依赖性突触的可塑性  

Calcium Dependent Synaptic Plasticity

作　　者：窦颖[1] 严进[2] 吴■ 崔瑞耀[1] 路长林[2] 

机构地区：[1]青岛大学医学院病理生理学教研室,青岛266021 [2]第二军医大学神经生物学教研室

出　　处：《生理科学进展》2001年第1期35-38,共4页Progress in Physiological Sciences

基　　金：国家自然科学基金(39670259,3990080);军队医药卫生科研基金(96M077,98M079)资助课题

摘　　要：突触前和突触后细胞内钙离子 ([Ca2 +]i)在短时程和长时程突触的可塑性中 ,发挥着重要的信息传递作用。兴奋后残留 [Ca2 +]i,可以激发短时程突触增强。突触前 [Ca2 +]i 可以影响被抑制的突触前膜囊泡的更新 ,并准确编码突触前和突触后信息 ,产生截然相反的长时程突触修饰 (LTP或LTD)。Recent work shows that the intracellular free Ca 2+ concentrations ([Ca 2+ ] i) of the presynaptic and postsynaptic neurons play crucial signaling roles in short and long term synaptic plasticity. Residual [Ca 2+ ] i followed conditioning stimulation may cause short term synaptic enhancement. Presynaptic [Ca 2+ ] i could influence the replacing of presynaptic depressed vesicles, as well as encode the precise relative timing of presynaptic input and postsynaptic activity and generate long term synaptic modification of opposite polarity(LTP or LTD).

关 键 词：细胞内钙离子 突触 可逆性 

分 类 号：R338.13[医药卫生—人体生理学]