不同负荷剂量右美托咪定对SICU患者镇静诱导期血流动力学的影响  

The effects of dexmedetomidine for different loading dose on blood pressure of SICU patients conscious-sedation derivative phase

作　　者：蒋正英[1] 吴桂新[1] 张宁[1] 袁建国[1] 

机构地区：[1]重庆市肿瘤研究所重症医学科,400030

出　　处：《重庆医学》2014年第5期516-517,520,共3页Chongqing medicine

摘　　要：目的研究不同负荷剂量右美托咪定对外科重症监护病房(SICU)患者镇静诱导期血流动力学的影响。方法选择全身麻醉患者60例,术后予以右美托咪定镇静,随机分为常规剂量组(1.00μg/kg,C组)、中剂量组(0.75μg/kg,M组)和低剂量组(0.50μg/kg,L组),负荷时间10min。采用Ramsay镇静评分评估镇静效果。监测给药前,给药后5、15、30、60min时患者的平均动脉压,对其安全性进行评估。结果各组患者均达到良好镇静效果。C组给予负荷剂量后血压显著下降;L组、M组患者给药后血压有所下降,但随时间推移血压能回升。给药60min后,C组患者平均动脉压显著低于L组及M组,差异有统计学意义(P<0.05)。结论对于SICU患者镇静诱导期,给予低剂量右美托咪定负荷能达到良好的镇静,对血流动力学影响更小。Objective To observe the effects of dexmedetomidine for different loading dose on blood pressure of surgery inten-sive care unit（SICU） patients conscious-sedation derivative phase .Methods 60 patients after general anaesthesia were divided into routine dose group（dexmedetomidine 1 .00 μg/kg ,group C） ,middle dose group（dexmedetomidine 0 .75 μg/kg ,group M ） and low dose group（dexmedetomidine 0 .50 μg/kg ,group L） ,and the loading time were reset 10 min .sedative effect was evaluated by Ram-say sedation score .Record the mean arterial blood pressure of everyone before administration ,5 min after ,15 min after ,30 min af-ter ,60 min after .Results All patients achieved good conscious-sedation .Compared with pro-administration ,the mean arterial blood pressure of group C descend significantly .The mean arterial blood pressure of group M and L descend significantly ,and then they were recover over time .60 min after the treatment ,the mean arterial blood pressure in group C was significantly lower than group L and goup M （P〈0 .05） .Conclusion Small dose dexmedetomidine can achieved good conscious-sedation for SICU patients .It has less influence on hemodynamics .

关 键 词：重症监护病房 血流动力学 血压 清醒镇静 

分 类 号：R614[医药卫生—麻醉学]