小鼠肾脏中CD133表达的研究  

The expression research of CD133 in mouse kidney

作　　者：刘伟[1] 马云胜[1] 穆长征[1] 田鹤[1] 

机构地区：[1]辽宁医学院组织学与胚胎学教研室,辽宁锦州121000

出　　处：《重庆医学》2014年第5期587-588,591,共3页Chongqing medicine

摘　　要：目的观察成熟小鼠肾脏中CD133的表达定位,分析其分布规律,为肾脏的修复再生研究提供依据。方法心脏灌流固定取成熟小鼠肾脏,制成5μm厚石蜡切片。然后行CD133的免疫组织化学检测。结果 CD133表达于髓质肾乳头区,少量表达于外髓外带远端小管和集合管以及皮质肾单位远端小管。结论肾脏乳头区可能是肾脏干细胞密集以及再生能力较强的区域。Objective To observe the expression of CD133 in mouse kidney ,analysis the distribution pattern ,and provide basis for the kidney regeneration research .Methods The mice kidney was took by the heart perfusion fixation ,and then made into 5 μm thick slice .Immunohistochemistry test was used to detect the CD133 expression .Results CD133 was mostly expressed in renal pa-pallie zone ,and also could be seen at the distal tubule in outer zone of medulla external and the distal tubule in the superfacial neph-ron .Conclusion The renal papallie zone might have mass renal stem cells and regeneration capacity .

关 键 词：小鼠 肾 干细胞 CD133 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学]