四川地区1465例艾滋病患者机会性感染分析  

AIDS patients with opportunistic infections in Sichuan province:clinical analysis of 1465 cases

作　　者：何盛华[1] 周锐锋[1] 刘大凤[1] 蔡林[1] 王印[1] 周晓飞[1] 张毅[2] 张春兰[1] 刘晓霞[1] 张峣[3] 

机构地区：[1]四川省成都市传染病医院感染科,610061 [2]四川省中医药科学院,成都610041 [3]中国疾病预防控制中心性病艾滋病预防控制中心艾滋病治疗与关怀室,北京100050

出　　处：《重庆医学》2014年第5期592-593,596,共3页Chongqing medicine

基　　金：四川省卫生厅课题(090016)

摘　　要：目的探讨四川地区艾滋病(AIDS)患者合并机会性感染的临床特点及其对预后的影响。方法回顾性分析成都市传染病医院近10年1 465例AIDS住院患者合并机会性感染的临床资料。结果 AIDS合并机会性感染患者住院期间总病死率15.49%,导致死亡的常见机会性感染是重症肺炎150例(74.62%)、中枢神经系统感染47例(23.86%);常见的疾病种类是细菌性肺炎、肺孢子菌肺炎、深部真菌病、结核病;常见的感染部位是呼吸道、口咽部、中枢神经系统、消化道、皮肤。同时患两种及以上的机会性感染疾病占50.77%;感染同时累及2个部位占42.18%、3个及以上占17.20%。结论四川地区AIDS患者合并机会性感染具有自身的临床特点,多部位及多种感染同时存在、病情复杂严重,是目前AIDS患者死亡的主要原因。Objective To study clinical characters and prognosis of AIDS patients with opportunistic infections in Sichuan prov-ince .Methods We performed an retrospective analysis of 1 465 AIDS patients with opportunistic infections who were admitted into the transmitted disease hospital of Chengdu in recent 10 years .Results The overall mortality during hospitalization was 15 .49% . The leading cause of death was respiratory failure due to pneumonia （n=150 ,74 .62% ） or meningitis（n=47 ,23 .86% ） .Descending rank order of common opportunistic infections were respiratory tract ,the mouth swallows ,central nervous system ,gastrointestinal tract skin ,blood system .Descending rank order of common sites of infections were respiratory tract ,oropharynx ,central nervous system ,gastrointestinal tract skin ,reproductive tract .The multiple infections are common ：more than 50% of patients suffering from two or more infections（50 .77% ） .Complexity of infection sites ：42 .18% dual infection sites and 17 .20% three or more infec-tion sites .Conclusion The opportunistic infections disease spectrum of AIDS in Sichuan area has its own characteristics ：multiple infections and multiple infections sites are both common ,death risks are high ,conditions of patients are severe generally ,and respir-atory failure is the main cause of death .

关 键 词：获得性免疫缺陷综合征 机会性感染 临床特点 预后 

分 类 号：R512.91[医药卫生—内科学]