双价肾综合征出血热灭活疫苗加强免疫后中和抗体反应  

Neutralizing Antibody Reaction after Secondary Immunization with Bivalent Inactivated Vaccine for Epidemic Hemorrhagic Fever

作　　者：李岩金[1] 陆群英[1] 朱智勇[1] 赵丽娟 

机构地区：[1]浙江省疾病预防控制中心,杭州310009 [2]杭州天元生物药业公司

出　　处：《中国媒介生物学及控制杂志》2001年第1期63-64,共2页Chinese Journal of Vector Biology and Control

摘　　要：目的 :双价肾综合征出血热 (HFRS)灭活疫苗基础全程 3针免后 1年半加强 1针免疫 ,观察两型的中和抗体反应水平。方法 :对免疫志愿者加强免疫前和免疫后 2 0d采血 ,以空斑减少中和试验 (PRNT)检测血清中HFRSⅠ型 ( 76 - 118)和Ⅱ型 (SEOV)中和抗体。结果 :血清学检测加强免疫后Ⅰ型中和抗体滴度GMT 1∶2 8.2 9,Ⅱ型中和抗体滴度为 1∶32 .49,比加强免疫前两型中和抗体滴度高 3～ 10倍。结论Objective:To observe the neutralizing antibody reaction after secondary immunization with Bivalent inactivated vaccine for epidemic hemorrhagic fever. Methods:Some volunteers were injected with bivalent inactivated vaccines for epidemic hemorrhagic fever(HFRS).3 doses were for primary immunization and one dose for secondary immunization after one and half year's interval.Neutralizing antibodies (NA) against HTNV and SEOV in sera before and after secondary immunization were detected by a plaque reduction neutralization test(PRNT). Result:The GMT of NA against HTNV and NA against SEOV after secondary immunization were 1∶ 28.29 and 1∶ 32.49 ,respectively.The GMT of NA increased (3-10 fold)compared with that before secondary immunization.

关 键 词：双价肾综合征出血热灭活疫苗 加强免疫 中和抗体 HFRS 肾综合征出血热 

分 类 号：R512.8[医药卫生—内科学]