三丁酸甘油酯中维生素A热处理反应产物研究  

Study on reaction products of vitamin A in tributyrin under heating

作　　者：尹红[1] 俞安[1] 盛财平 袁慎峰[1] 陈志荣[1] 

机构地区：[1]浙江大学化学工程与生物工程学系,浙江杭州310027

出　　处：《浙江大学学报（工学版）》2013年第12期2170-2175,共6页Journal of Zhejiang University：Engineering Science

基　　金：国家"863"高技术研究发展计划资助项目(2009AA033301);浙江省重点科技创新团队计划资助项目(2011R50007)

摘　　要：为了考察维生素A的稳定性,在避光无氧条件下,采用高效液相色谱(HPLC)及其自带的二极管阵列检测器(DAD)和液质联用仪(HPLC/MS)分析了维生素A醋酸酯(VAA)在三丁酸甘油酯中热处理时生成的副产物类型,跟踪分析了6个不同温度下各物质质量分数随时间的变化情况.研究表明:低温时VAA主要发生异构化反应生成VAA异构体,高温时VAA主要发生异构化反应、脱水反应和二聚反应生成VAA异构体、脱水维生素A和二聚体.Vitamin A acetate（VAA）was heated at six different temperatures in tributyrin in the absence of oxygen and light in order to investigate the storage stability of vitamin A.HPLC with diode array detector（DAD）and HPLC with mass spectrometer（MS）were applied to analyze the structures of the by- products,and the mass fraction of VAA and various by-products were given with the time progressing as well.It is found that at low temperatures,the isomerization plays a leading role and VAA isomers are the main products;while at high temperatures,three reactions,namely isomerization,dehydration and dimerization,take place in this process,and VAA isomers,anhydrovitamin A and vitamin A dimers are the main products.

关 键 词：维生素A醋酸酯 三丁酸甘油酯 异构化 脱水反应 二聚反应 

分 类 号：TQ466.1[化学工程—制药化工]