旅行者腹泻区域间病因学差异分析  

Etiologic analysis of traveler's diahrrea in different geographic region

作　　者：秦佳[1] 韩晓辉[1] 李俊[1] 周启明[1] 叶魏[1] 张琳[1] 章琪[1] 

机构地区：[1]上海国际旅行卫生保健中心,上海200335

出　　处：《中国国境卫生检疫杂志》2013年第6期391-395,共5页Chinese Journal of Frontier Health and Quarantine

基　　金：上海检验检疫局科研基金项目(HK034-2014)

摘　　要：目的比较旅行者腹泻(traveler’s diahrrea,TD)病原体的区域间差异,以期为预防和治疗提供依据。方法检索1973年至今发表于Pubmed(Medline)和中国知网的TD相关文献,对TD发生次数、人数、病原体、区域等因素进行整理及分析。结果经统计,肠产毒性大肠杆菌(Enterotoxic escherichia coli,ETEC)为最常见病原体,占总TD发病人数的30.86%(1 944/6 300),其中拉丁美洲、非洲和南亚阳性率最高,分别占该区域TD总数的33.59%(1 109/3 302)、31.22%(385/1233)和30.42%(223/733)。其余较高的病原体为肠黏附性大肠杆菌(Enteroadherent Escherichia coli,EAEC)和诺如病毒(Norovirus,NV)。ETEC、EAEC、肠致病性大肠杆菌(Enteropathogenic Escherichia coli,EPEC)、肠出血性大肠杆菌(Enterohemorrhagic Escherichia coli,EHEC)、弯曲杆菌、志贺氏菌、沙门氏菌、气单孢菌、毗邻单胞菌、非霍乱弧菌、贾第鞭毛虫、隐孢子虫、阿米巴原虫的感染均有地区间差异。结论TD的病原体存在地区间差异,了解该差异对TD的预防和治疗具有一定指导意义。Objective To analyze the regional differences of pathogen of traveler＇ s diahrrea（TD）, and to preserve the basis for clinical prevention and treatment. Methods The literatures on TD published on Pubmed （Medline） and CNKI data base were retrieved, and the factors such as frequency, pathogen and regions were analyzed. Results Enterotoxigenic E. coli （ETEC） was the most common pathogen which was detected in 30.86% （1 944/6 300）, with Latin America 33.59% （1 109/3 302）, Africa 31.22% （385/1 233）, Southeast Asia 30.42% （223/733） of all the TD numbers in the region, respectively. The second and third most common pathogen detected were entero adherent Escherichia coli（EAEC） and Norovirus（NV）. Other significantly regional differences were seen for Enteroadherent Escherichia coli, Enteropathogenic Escherichia coli, Enterohemorrhagic Escherichia coli, Campylobacter, Shigella, Salmonella, Aeromonas, Plesiomonas, Non-cholerae Vibrio Species, Giardia, Cryptosporidium, E.histolytica. Conclusion There are regional differences on TD pathogens. The identification of TD pathogen in different regional will serve as a baseline for antimicrobial therapy recommendations and prophylaxis strategies.

关 键 词：旅行者腹泻 病原体 区域间 病因学 分析 

分 类 号：R181.3[医药卫生—流行病学]