缬沙坦对自发高血压大鼠左室肥厚心肌Kv4.2表达的影响  

Effect of Valsartan on the Expression of Kv4.2 in Left Ventricular Hypertrophic Myocardium of Spontaneously Hypertensive Rat

作　　者：黄至斌[1] 林茂欢[2] 袁桂仪[2] 

机构地区：[1]中山大学附属第一医院心内科,510080 [2]中山大学孙逸仙纪念医院心内科

出　　处：《岭南急诊医学杂志》2013年第6期410-411,430,共3页Lingnan Journal of Emergency Medicine

基　　金：广东省科技计划社会发展项目(20108031600060)

摘　　要：目的:探讨缬沙坦对自发高血压大鼠(SHR)左室肥厚心肌Kv4.2表达的影响。方法:将16只10周龄雄性SHR随机分成缬沙坦组和非缬沙坦组各8只:8只10周龄Wistar-Kyoto大鼠为对照组。喂药8周后分别测定各组大鼠动脉收缩压、左室质量指数(LVMI)、左室心肌Kv4.2的表达。结果:非缬沙坦组和缬沙坦组LVMI明显大于对照组(3.7+0.02 mg/g and 3.2-0.03mg/g vs 2.5±0.03mg/g,P<0.0叭),非缬沙坦组LVMI明显大于缬沙坦组(3.7±+0.02 mg/g vs 3.2+0.03 mg/g,P<0.001);非缬沙坦组和缬沙坦组左心室心肌Kv4.2表达明显低于对照组(P<0.01),缬沙坦组左心室心肌Kv4.2的表达明显高于非缬沙坦组(P<0.01)。结论:缬沙坦通过逆转SHR左室心肌肥厚提高左室心肌Kv4.2的表达。Objective：To investigate the effect of Valsartan on the expression of Kv4.2 in left ventricular hypertrophic myocardium of spontaneously hypertensive rat （SHR）. Methods： 16 male SHR were divided into 2 groups： valsartan and non valsartan group （n=8）. The 10-week Wistar-Kyoto rat was served as controlled group （n= 8）. Kv4.2 expression was measured in left ventricular myocardium by the Western-Blot technique, and the systolic blood pressure （SBP） and left ventricular mass index （LVMI） were measured respectively after eight weeks. Results： The LVMI was significantly higher in non valsartan group and valsartan group, respectively than that in control group （3.7±0.02 mg/g and 3.2±0.03 mg/g vs 2.5±0.03 mg/g,P〈0.001）.The LVMI were significantly higher in non- Valsartan group than that in Valsartan group （3.7±0.02 mg/g vs 3.2±0.03 mg/g, P〈0.001）.The expression of Kv4.2 was significantly lower in non valsartan group and valsartan group, respectively than that in control group （P〈0.001）. The expression of Kv4.2 was significantly higher in valsartan group than that in non-Valsartan group （P〈0.001）. Conclusion：Valsartan improve the expression of Kv4.2 by reversing the left ventricular hypertrophy in spontaneously hypertensive rats.

关 键 词：血管紧张素Ⅱ受体拮抗剂 心肌肥厚 Kv4 2 

分 类 号：R544.1[医药卫生—心血管疾病] R541.3[医药卫生—内科学]