年龄对新生儿高未结合胆红素血症疗效的影响  

Effect of age on therapy of neonatal unconjugated hyperbilirubinemia

作　　者：陈风展[1] 

机构地区：[1]江苏省泰州市第二人民医院儿科,江苏秦州225599

出　　处：《中国医学工程》2013年第12期27-28,共2页China Medical Engineering

摘　　要：目的探讨新生儿高未结合胆红素血症患儿入院时的年龄对以光疗为主的综合治疗疗效的影响。方法按照患儿入院时年龄分为三组:<4 d为1组,共17例;4 d≤年龄<8 d为2组,共22例;≥8 d为3组,共40例。观察各组性别、胎龄、出生体重、喂养方式以及使用肝酶诱导剂、茵栀黄等情况。对三组入院时总胆红素及2次光疗12 h后总胆红素减少的量进行比较。结果三组患儿性别、胎龄、出生体重、喂养方式、使用肝酶诱导剂、茵栀黄等情况及入院时总胆红素无显著性差异。2次光疗12 h后1组总胆红素减少量(99.14±53.75)μmol/L明显低于2组(135.57±31.85)μmol/L和3组(122.84±33.35)μmol/L,有显著性差异(F=4.430,P=0.015)。结论出生<4 d新生儿高未结合胆红素血症进行光疗为主的综合治疗早期疗效可能没有4 d以上者好,应引起临床重视。【Objective】To investigate the effect of the age of admission on combined therapy of mainly phototherapy for neonatal unconjugated hyperbilirubinemia. 【Methods】According to the age of admission, the children were divided into three groups. Those children whose age is 4 days were into Group 1（n=17）, 4 days ≤ age 8 days into Group 2（n=22）,≥ 8 days into Group 3（n=40）. The gender, gestational age, birth weight, feeding patterns, the use of liver enzyme inducer and Yinzhihuang, total serum bilirubin（TSB） on admission and after twice phototherapy of 12 hours of three groups were compared. 【Resluts】There is no significant difference among the three groups of the gender, gestational age, birth weight,feeding manner, the use of liver enzyme inducer and Yinzhihuang, and TSB on admission. After phototherapy for twice12 hours, the reduction of TSB in Group 1（99.14 ± 53.75） μ mol/L is significantly lower than that in Group 2（135.57± 31.85） μ mol/L and in Group 3（122.84 ± 33.35） μ mol/L（F=4.430, P=0.015）. 【Conclusion】It should lead to clinical attention that the early effect of combined treatment of mainly phototherapy on neonate born less than 4 days with unconjugated hyperbilirubinemia might be worse than those born more than 4 days.

关 键 词：年龄 新生儿 高未结合胆红素血症 光疗 

分 类 号：R722.17[医药卫生—儿科]