替罗非班以及不同给药途径对AMI患者PCI术后sICAM-1的影响  

The Effects of Tirofiban and Different Administration of Tirofiban on Level of sICAM-1in Acute Myocardial Infarction Patients after Percutaneous Coronary Intervention

作　　者：吴婷婷[1] 张晓[1] 朱记法[1] 张由建[2] 

机构地区：[1]郑州大学第一附属医院,河南郑州450052 [2]河南省胸科医院心内科,河南郑州450052

出　　处：《医学与哲学（B）》2013年第12期66-68,共3页Medicine & Philosophy(B)

摘　　要：探讨替罗非班以及不同给药途径对急性心肌梗死(AMI)患者经皮冠状动脉介入术(PCI)后可溶性细胞间粘附因子-1(sICAM-1)的影响。选择AMI直接PCI患者90例随机分成A、B、C三组:A组不给予替罗非班;B组PCI术后静脉给予替罗非班,C组PCI术中对梗死相关冠状动脉(IRA)内注射替罗非班,两组均静脉滴注36h;分别检测三组术前及术后24h血浆sICAM-1的浓度水平。结果显示,A组PCI术后24h血浆sICAM-1的浓度水平较术前高,而B、C两组较术前均降低,差异有统计学意义(P<0.05),但B、C两组PCI术后差异无统计学意义(P>0.05)。因此,对于行PCI术的AMI患者应给予替罗非班,抑制术后炎症反应以及粘附反应,降低PCI术后再狭窄的发生率,但其作用效果与给药途径无关。To explore the effects of tirofiban and different administration of tirofiban on level of sICAM-- 1 in acute myocardial infarction （AMI） patients after pereutaneous coronary intervention （PCI）. 90 patients with AMI undergoing PCI were randomly divided into group A, group B and group C. Group A did not receive tirofiban neither via intracoronary （IC） nor intravenous （IV） route. Group B after PCI received tirofiban via IV route, Group C during PCI received tirofiban via IC route and both of them were followed by a 36 hours of IV infusion. The plasma levels of slCAM-- 1 before PCI and 24 hours after PCI were measured. The result showed that the postoperative plasma levels of sICAM-- 1 of Group A increased compared with the preoperative levels and the difference was statistically significant （P%0.05）, which was iust opposite with Group B and Group C. There were no significant differences between Group B and Group C（P~〉0.05）. Therefore, the influence of tirofiban for sICAM--1 of AMI patients treated with PCI is obvious and the effect is independent with the route of administration.

关 键 词：替罗非班 急性心肌梗死 冠状动脉介入术 可溶性细胞间粘附因子-1 

分 类 号：R542.22[医药卫生—心血管疾病] R973.2[医药卫生—内科学]