冠心病中西药联合用药的横断面研究  

A Cross-sectional Study on Integrated Chinese and Western Medicine to Treating Coronary Heart Diseases

作　　者：王佟[1] 高铸烨[2] 焦阳[3] 韩文忠[1] 郭华[1] 郭晓平[1] 

机构地区：[1]河北省沧州市中西医结合医院心内科,沧州061000 [2]中国中医科学院心血管病研究所,北京100091 [3]北京中医药大学,北京100029

出　　处：《世界中医药》2013年第12期1389-1392,共4页World Chinese Medicine

基　　金：国家自然科学基金(编号:81303150)

摘　　要：目的:调查分析沧州中西医结合医院冠心病住院患者的联合用药状况。方法:采用临床流行病学横断面调查方法,利用医院信息系统(Hospital Information System,HIS)提取冠心病住院患者的一般临床资料及诊断用药数据,采用SPSS13.0软件对联合用药情况进行描述性分析。结果:643例冠心病患者符合入选标准,其中心绞痛308例(占47.90%)、心力衰竭238例(占37.01%)、急性心肌梗死97例(占15.09%)。年龄29～91岁,平均(64.39±12.44)岁;男性417例(64.85%),女性226例(35.15%)。患者住院天数1～48 d,平均住院(12.15±5.82)d。主要并存疾病是糖尿病、高血压、高脂血症、呼吸系统疾病、脑血管疾病、慢性肾功能不全,以4～6种疾病共存为多见。共计应用西药2～33类,77种,平均(7.54±3.83)类,(16.38±7.31)种。513例(79.78%)患者使用了中成药,总计79种,单个患者使用3～18种,平均使用(10.68±4.21)种。376例(58.48%)患者服用了中药汤剂,中药汤剂药味4～50味,平均(16.18±6.37)味;联合用药(包括中药、中成药、西药)数2～60种,平均用药(18.49±9.24)种,77%以上的患者使用了5～26种药物。结论:冠心病常多种疾病并存,联合用药是治疗冠心病的常用策略,药物联合应用的交互作用、临床疗效和安全性有待进一步研究。Objective： To analyze combined treatment status of hospitalized patients with coronary heart disease（ CHD） admitted in Can- gzhou Integrative Medicine Hospital. Methods： Cross-sectional study methods of clinical epidemiology were conducted. The Hospital In- formation System（ HIS） was used to extract general clinical data and diagnostic drug data of hospitalized patients with CHD. SPSS13. 0 software was used to analyze drug combination. Results： There were altogether 643 cases meeting the inclusion criteria,among which 308 cases were angina pectoris（ accounting for 47. 90%）,238 cases were heart failure（ accounting for 37. 01%） and 97 cases were acute myocardial infarction（ accounting for 15. 09%）. The patients＇ ages ranged from 29 to 91 years old,with an average age of（ 64. 39 ± 12. 44） years old. There were 417 male cases（ 64. 85%） and 226 female cases（ 35. 15%）. Patients were in hospital for 1 to 48 days with an average of（ 12. 15 ± 5. 82） days. Major comorbidities were diabetes,hypertension,hyperlipidemia,disease of respiratory sys- tem,cerebrovascular disease and chronic renal insufficiency,and patients were usually with 4 to 6 diseases. Western medicine applied were 2 to 33 categories with 77 kinds,averagely（ 7. 54 ± 3. 83） categories and（ 16. 38 ± 7. 31） kinds. There were 513（ 79. 78%） patients used 79 kinds of Chinese patent medicine,averagely（ 10. 68 ± 4. 21） kinds. Altogether 376 cases（ 58. 48%） patients took the decoction,and the herbal medicines in a prescription were 4-50 species,averagely（ 16. 18 ± 6. 37） species. Integrated western and Chinese medicine（ including traditional Chinese medicine,Chinese patent drug and western medicine） used were 2 to 60 categories,with an average of（ 18. 49 ± 9. 24） categories. 77% of patients used 5 to 26 pharmaceutical composition. Conclusion： The multiple disea- ses coexisted with CHD. Integrated Chinese and Western medicine was commonly used for treatment strategies of CHD. Interact

关 键 词：冠心病 联合用药 交互作用 

分 类 号：R969[医药卫生—药理学]