兔直肠黏膜内脱垂模型的建立  

The Animal Model of Internal Rectal Prolapse in Rabbits

作　　者：柯敏辉[1] 叶玲[1] 陈立武[1] 吴华嵩[2] 魏霖[1] 郑鸣霄[1] 

机构地区：[1]福建中医药大学附属第二人民医院,福州350003 [2]福建省中医药研究院,福州350003

出　　处：《世界中医药》2013年第12期1458-1460,1464,共4页World Chinese Medicine

基　　金：国家自然基金(编号:81173272);福建省中医临床研究基地重点专科(专病)项目(编号:zlcgc04)

摘　　要：目的:研制IRP兔模型。方法:取新西兰兔30只,随机分成正常组与造模组。造模组采用大黄和番泻叶灌胃、无水乙醇肛周注射与站立三种方法联合造IRP兔模型。比较正常组与造模组肛镜下直肠黏膜脱垂情况及直肠壁显微结构情况。结果:与正常组相比,造模组直肠黏膜内脱垂明显,直肠壁病理征象符合IRP的标准。结论:复合方法造IRP兔模型,方法可靠。Objective： To develop IRP rabbit model. Methods： Thirty New Zealand rabbits were randomly divided into normal group and model group. Three methods were conducted to make the rabbit models. The three methods contain rhubarb and senna gavage,peri- anal injection of anhydrous alcohol and stand. The prolapse of rectal mucosa under the anus mirror and the microscopic structure of rec- tum between the normal group and the model group were compared. Results： Compared with the normal group,internal rectal prolapse were significantly different in the model group. Pathological findings were in accordance with IRP standards. Conclusion： Composite method of IRP rabbit model is reliable.

关 键 词：直肠黏膜内脱垂 兔 动物模型 

分 类 号：R657.18[医药卫生—外科学]