NICU病原菌的分布及耐药性特点分析  

Distribution and drug resistance characteristics analysis of NICU patogenic bacteria

作　　者：范克满[1] 王世富[1] 王素兰[1] 贾云霞[1] 蒋芙蓉[1] 于凤玲[1] 张乐海[1] 

机构地区：[1]山东大学齐鲁儿童实验诊断中心,山东济南250022

出　　处：《医学检验与临床》2013年第6期23-26,共4页Medical Laboratory Science and Clinics

摘　　要：目的：了解NICU病房病原菌的分布及耐药性特点,为NICU感染的临床治疗提供依据，以指导临床合理用药，并为院内感染控制提供理论支持。方法：严格按照《全国临床检验操作规程》对NICU病房的标本进行进行分离及鉴定，采用K-B法进行药敏试验，应用WHONET5和SPSS10.0进行统计分析。结果：NICU科分离的69株肺炎克雷伯菌耐药性较强，其对头孢哌酮/舒巴坦、头孢吡肟、头孢他啶的敏感分别为44.9%、7.2%、7.2%，远低于我院其他科室分离的肺炎克雷伯菌对这三种药物敏感性的平均值（分别为64.6%、36%、33.6%），具有显著性差异；但其对亚胺培南和美洛培南的敏感率无显著性差异。结论：NICU感染的肺炎克雷伯菌可能来自分娩时母体（即成人感染的肺炎克雷伯菌），其对头孢哌酮/舒巴坦、头孢吡肟、头孢他啶敏感性较儿童感染的肺炎克雷伯菌的敏感性明显降低，临床微生物室应加强NICU肺炎克雷伯杆菌的检测工作，NICU分离到的肺炎克雷伯菌的药敏的差异值得引起NICU科大夫的注意。Objective：To understand the NICU ward of the pathogen distribution and drug resistance characteristic, for the clinical treatment of NICU infection provides the basis, to guide clinical rational drug use, and for nosocomial infection control to provide theory support. Methods：In strict accordance with the national clinical inspection operating rules of NICU ward of specimens from separation and identification, and adopts k-b method of drug sensitive test, the application WHONET5 SPSS10.0 and statistical analysis.Results：69 strains separated NICU pneumonia clay ＆quot;bacteria strong resistance, on the cefoperazone/sulbactam , cefepime, cefotaxime sensitive were 44.9%, 7.2%, 7.2%, much lower than other department of our separation of this bacteria pneumonia clay＆quot;three drugs sensitivity average （were 64.6%, 36%, 33.6%）, has a significant difference; But its imipenem and culture of south los sensitive rate no significant differences. Conclusions：NICU pneumonia clay＆quot;may come from bacteria during the matrix （i.e. adult pneumonia clay＆quot;bacteria）, the cefoperazone/sulbactam was, cefepime, cefotaxime sensitivity than children pneumonia clay＆quot;bacteria to the sensitivity of the reduced significantly, and clinical microbial room should strengthen the NICU pneumonia clay＆quot; bacillus testing work, NICU from pneumonia clay＆quot;bacteria medicine quick difference is worth causing the NICU, the attention of the doctor.

关 键 词：NICU 病原菌 肺炎克雷伯杆菌耐药性 

分 类 号：R47-4[医药卫生—护理学]