注射用多索茶碱与注射用阿洛西林的配伍稳定性考察  

Study on the Compatible Stability of Doxofylline Injection and Azlocillin Injection

作　　者：陈青华[1] 田自有[1] 胡静洁[2] 

机构地区：[1]台州市中心医院药剂科,浙江台州318000 [2]温州医学院,浙江温州325035

出　　处：《中国现代应用药学》2014年第1期110-112,共3页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的考察注射用多索茶碱与注射用阿洛西林的配伍稳定性。方法观察并测定注射用多索茶碱与注射用阿洛西林在0.9%氯化钠注射液中配伍后于室温条件下放置6 h内的外观及pH值,并采用高效液相色谱法测定配伍液的含量。结果与配伍后0 h比较,配伍液在6 h内的外观和含量都没有明显的变化,而pH值有所浮动。结论注射用多索茶碱与注射用阿洛西林在0.9%氯化钠注射液中配伍后于室温下放置6 h内质量较稳定。OBJECTIVE： To study the compatible stability of doxofylline injection and azlocillin injection. METHODS： The changes in appearance and PH value of the mixture of doxofylline injection and azlocillin injection in 0.9% sodium chloride injection within 6 hours at room temperature were observed and detemined,the contect of which determined by HPLC. RESULTS： Compared with the solution at 0h after mixing,no significant changes were found in appearance and content within 6 hours mixing,however,there was a fluctuation in its PH value. CONCLUSION： the mixture of doxophylline and azlocollin in 0.9% Sodium chloride is stable in quality wthinin 6 hours mixing at room temperature.

关 键 词：注射用多索茶碱 注射用阿洛西林 配伍 稳定性 高效液相色谱法 

分 类 号：R969.2[医药卫生—药理学]