大鼠海马结构CA1位置细胞对感觉错配适应的相关反应  

Relative Response of Hippocampal Formation CA1 Place Cell to the Adaptation of Sensory Mismatch in Rat

作　　者：邹丹[1] 吴敏范[2] 金戈[1] 符文双[3] 郑燕[4] 

机构地区：[1]沈阳医学院 病理生理学教研室 [2]沈阳医学院生理学教研室 [3]沈阳医学院机能实验中心 [4]沈阳医学院2012级临床医学,沈阳110034

出　　处：《中国医科大学学报》2014年第2期146-149,共4页Journal of China Medical University

基　　金：教育部留学归国人员科研启动基金(2013-693)

摘　　要：目的观察大鼠经过学习其海马结构接受视觉-前庭-本体感觉错配格局并将其视为匹配的状态后CA1位置细胞的电活动,为揭示海马结构可编码感觉输入的任何组合提供依据。方法应用微电极细胞外记录方法,记录清醒大鼠在适应视觉-前庭-本体感觉错配条件后海马结构CA1位置细胞神经元放电情况。结果 56个位置细胞中,29个神经元在正向状态中有显著的空间放电(正向相关神经元),19个神经元在反向状态中有显著的空间放电(反向相关神经元)。位置野内放电频率的分布呈现不对称及负偏斜。结论大鼠海马结构位置细胞可编码不能自然发生的新的感觉输入配置,更新海马结构比较器内的信息。Objective To study the discharge change of CA 1 place cells after hippocampal formation （HF） accepting the visual-vestibular-proprio- eeptive mismatch configuration as a match by learning, which could provide new scientific experimental data for revealing the fact that HF may en- code any cornbination of sensory inputs. Methods The unit discharge of CA1 place cells were recorded in an awake rat by using extraeellular micro- electrode record and stereotaxic techniques after the rat adapted to sensory mismatch. Results Out of 56 place cells, 29 showed predominant spatial firings in the forward sessions （forward-related neuron ）, while 19 showed predominant spatial firings in the backward sessions （backward-related neuron）. Firing rate distributions in the place fields were negatively skewed and asymmetric. Conclusion HF place cells have the ability to encode a new configuration of sensory input which does not occur naturally to update information in the HF eomparator.

关 键 词：感觉错配 海马 位置细胞 神经元放电 

分 类 号：R338.8[医药卫生—人体生理学]