三维适形放射治疗解除恶性胆道梗阻疗效的实验研究  

Experimental Study of 3D CRT Effect on Malignant Biliary Obstruction

作　　者：李玉泽[1,2] 任克[1] 李光[3] 徐克[1] 

机构地区：[1]中国医科大学附属第一医院放射科,沈阳110001 [2]解放军第202医院放射科,沈阳110812 [3]中国医科大学附属第一医院放疗科,沈阳110001

出　　处：《中国医科大学学报》2014年第1期71-74,共4页Journal of China Medical University

基　　金：辽宁省科学技术计划项目(2012225013)

摘　　要：目的研究三维适形放射治疗(3D CRT)对兔VX2胆总管移植瘤所致胆道梗阻的疗效。方法通过VX2胆总管移植瘤建立胆道梗阻模型。实验兔被随机分为放疗组和对照组。放疗组接受放射治疗,对照组单纯饲养1周。比较放疗前后2组实验兔胆道扩张程度、肿瘤大小及微血管密度(MVD)。结果放疗组和对照组各纳入19只实验兔,放疗1周后放疗组肿瘤直径、胆总管管径及肝内胆管起始部管径明显低于放疗前(P均<0.01),且低于对照组单纯饲养1周后(P均<0.01)。放疗组与对照组MVD计数的差异具有统计学意义(t=11.43,P<0.01)。结论 3D CRT能够减轻兔VX2胆总管移植瘤所致的胆道梗阻程度。Objective To study the 3D CRT effect on rabbit biliary obstruction through transplantation of VX2 tumor into rabbit common bile duct. Methods Rabbit biliary obstruction models were built through transplantation of VX2 tumor into rabbit common bile duct, and then were divided into the treated group and the control group randomly. Rabbits in the treated group were treated with radiotherapy, while rabbits in the control group were fed only.The fnst and the second biliary expansion extents, tumor sizes and MVD were compared and analyzed between the treated and control groups. Results There were 19 experimental rabbits in the treated and control groups, respectively.One week after radiotherapy, tumor size, com- mon bile duct diameter and the start diameter of intrahepatic bile duct of the rabbits in the treated group obviously decreased compared to those be- fore radiotherapy （P 〈 0.01 ）, which were significantly lower than those in control group （P 〈 0.01 ）. There were statistical differences of MVD in the two groups （ t = 11.43, P 〈 0.01 ）. Conclusion Radiotherapy can reduce the degree of biliary obstruction caused by rabbit common bile duct VX2 tu-

关 键 词：三维适形放射治疗 恶性胆道梗阻 动物模型 兔VX2 

分 类 号：R815.6[医药卫生—放射医学]