养正消积胶囊减轻胃癌术后化疗不良反应的临床观察  

Clinical Observation of Yangzheng Xiaoji Capsules in the Treatment of ADR Induced by Chemotherapy after Gastric Cancer Surgery

作　　者：苏连明[1] 李海林[1] 王加良[1] 

机构地区：[1]牡丹江医学院附属红旗医院消化内科,黑龙江牡丹江157001

出　　处：《中国药房》2014年第7期657-659,共3页China Pharmacy

摘　　要：目的:观察养正消积胶囊对胃癌术后化疗不良反应的疗效。方法:62例胃癌术后患者随机分为两组,治疗组34例给予常规FOLFOX-4(奥沙利铂+5-氟尿嘧啶+亚叶酸钙)化疗方案加用养正消积胶囊,每次4粒,每日3次;对照组28例单纯应用FOLFOX-4化疗方案。化疗结束后观察两组患者外周血象变化、生存质量及不良反应。结果:与对照组比较,治疗组外周血白细胞、血红蛋白与血小板下降幅度更小,差异有统计学意义(P<0.05);且治疗组KPS生存质量评分较高,不良反应较小(均P<0.05)。结论:养正消积胶囊可减少胃癌术后化疗的不良反应,提高患者生存质量。OBJECTIVE： To observe therapeutic efficacy of Yangzheng xiaoji capsules for ADR induced by chemotherapy after gastric cancer surgery. METHODS： 62 patients underwent gastric cancer surgery were randomly divided into 2 groups; 34 cases in treatment group were treated with conventional FOLFOX-4 chemotherapy regimens （oxaliplatin＋5-fluorouracil＋calcium folinate） combined with 4 pills of Yangzheng xiaoji capsules, 3 times a day; 28 cases of control group were only used FOLFOX-4 chemotherapy. After chemotherapy, the change of peripheral hemogram, quality of life and other ADR were observed in 2 groups. RESULTS ： Compared with control group, peripheral white blood cell, hemoglobin and platelet of treatment group decreased greatly, there was statistical significance（P〈0.05） ; high KPS score and slight ADR were found in treatment group （all P〈0.05）. CONCLUSIONS： Yangzheng xiaoji capsule can reduce ADR induced by chemotherapy after gastric cancer operation and improve the quality of life.

关 键 词：养正消积胶囊 胃癌 化疗 不良反应 

分 类 号：R283.65[医药卫生—中药学] R735[医药卫生—中医学]