黄芪注射液促进免疫功能低下小鼠T细胞增殖研究  

Astragalus Injection on Proliferation of T cell immune Function of Immunosuppressed mice

作　　者：杨巧红[1] 赵自明[2] 李琳琳[3] 杜标炎[1] 谭宇蕙[1] 周联[1] 连至诚[1] 郭玉荣[4] 苏俊芳[1] 张书征[1] 张根水[5] 刘艳玲 

机构地区：[1]广州中医药大学,广东广州510405 [2]广东省中医研究所,广东广州510405 [3]南方医科大学肿瘤研究所,广东广州510515 [4]广西柳州市中医院,广西柳州545001 [5]广州医学院,广东广州510405 [6]北大第三医院妇科生殖医学中心,北京100083

出　　处：《中国药物经济学》2014年第1期36-38,共3页China Journal of Pharmaceutical Economics

基　　金：广东省中医药管理局项目资助(2007058)

摘　　要：目的观察黄芪注射液对地塞米松(Dex)所致免疫功能低下小鼠T细胞增殖的影响。方法连续腹腔注射给药5天,末次给药后2h称小鼠体重。结果与对照组相比,模型组小鼠胸腺指数、血清与胸腺IL-2的含量均有显著减少(P<0.05),而胸腺PCNA表达面积累积百分比无显著差异(P>0.05)。结论黄芪注射液可抑制Dex所致免疫功能低下模型小鼠的胸腺萎缩,促进免疫功能的恢复。Objective To observe the effect of astragalus injection of dexamethasone（Dex） proliferation induced immunosuppressed mice T cels.Methods Besides control group,the other five groups were injected Dex 5 days for immunodeficient mice model,two hours after the final injection,weight recorded.Results Compared with the control group, thymus index and IL-2 of serum and thymus homogenate in model group were significantly reduced（P〉0.05）,but protein expression of PCNA had no significant difference（P〈0.05）.Conclusion Immunity was impaired in mice exposed to Dex,AI could play an important role in recovering the immune function,the mechanisms would be further researched.

关 键 词：免疫功能低下 黄芪注射液 地塞米松 

分 类 号：R285.5[医药卫生—中药学]