健脾清化方对局灶节段硬化模型大鼠α平滑肌肌动蛋白和Ⅳ型胶原的影响  

Effects of Jianpi Qinghua decoctions on α-SMA and Col IV in rats with focal segmental glomurular sclero-

作　　者：马晓红[1] 何立群[1] 

机构地区：[1]上海中医药大学附属曙光医院肾病科,上海201203

出　　处：《临床肾脏病杂志》2013年第12期564-566,共3页Journal Of Clinical Nephrology

基　　金：国家自然科学基金（Na81173219）;科技部中医药行业科研专项（NO201007005）;上海市科委创新行动计划项目（NQ11DZ1973100）;上海市教育委员会E-研究院建设计划资助项目（No.E03008）;上海高校创新团队建设项目

摘　　要：目的探讨健脾清化方对阿霉素致局灶节段硬化（focalsegmentalglomerularsclerosis，FSGS）模型大鼠肾功能的影响。方法左侧。肾切除加尾静脉注射阿霉素致大鼠肾脏FSGS，观察健脾清化方对模型大鼠0t平滑肌肌动蛋白（α-smoothmuscleactin，α-SMA）mRNA、lV型胶原（collagentypeIV，ColⅣ）mRNA的作用。结果与模型组比较，健脾清化方能显著降低α-SMAmRNA、ColⅣmRNA水平，且优于尿毒清组。结论健脾清化方对阿霉素肾病模型大鼠的肾纤维化有一定的改善作用，且疗效优于尿毒清。Objective To study the effect of Jianpi Qinghua decoctions on the renal function ol rats with focal segmental glomurular sclerosis （FSGS）. Methods The rat FSGS model was established by left nephreetomy plus intravenous injection of adriamyein into the tail vein. The effect of Jianpi Qin- ghua decoctions on the mRNA expression of a-smooth muscle actin （a-SMA） and collagen type IV（Col IV ） in rat FSGS mode[ was detected. Results The mRNA expression levels of a-SMA and Col IV in FSGS model group were significantly increased as compared with those in Jianpi Qinghua decoctions group after 56 days （P^0. 01）. Conclusions Jianpi in the rat model of adriamycin-induced nephropathy, particles. Qinghua decoctions can alleviate the renal fibrosis and have better therapeutic effect than Niaoduqing

关 键 词：健脾清化方 大鼠 阿霉素 

分 类 号：R692.31[医药卫生—泌尿科学]