白念珠菌耐药机制新进展  

New progress on the drug resistance mechanisms of Candida albicans

作　　者：颜钰[1,2] 曹颖瑛[1,2] 姜远英[1,2] 

机构地区：[1]福建中医药大学药学院中药学教研室,福州350000 [2]第二军医大学药学院新药研究中心,上海200433

出　　处：《中国真菌学杂志》2013年第5期311-315,共5页Chinese Journal of Mycology

基　　金：国家自然科学基金(81271798);国家973项目(2013CB531602)

摘　　要：近年来对于深部真菌感染的研究报道越来越多,其已日益成为一些重要疾病临床治疗过程中的常见并发症,其中,白念珠菌病的发病率仍居高不下。虽然目前有多种抗真菌药物应用于临床,但其耐药现象愈来愈严重,给临床治疗带来了极大的挑战。近来有关白念珠菌耐药机制的研究有了较新的进展。该文就新发现的白念珠菌的耐药机制,作一概述。In recent years,more and more research about deep fungal infections has been reported,it has increasingly become the common complications during the clinical treatment of several important diseases,among which,the incidence of candidiasis remains unacceptably high.Although there are many kinds of antifungal drugs used in clinic,the drug resistance is becoming more and more serious,which has brought great challenge to the clinical treatment.Recent studies on the mechanism of drug resistance of Candida albicans showed new progress.In this article,the new mechanisms of drug resistance about C.albicans are reviewed briefly.

关 键 词：白念珠菌 耐药机制 进展 

分 类 号：R379.4[医药卫生—病原生物学]