MALDI-TOF MS技术在临床病原真菌鉴定中的应用进展  

Advances in the application of Matrix-assisted laser desorption ionization time-of-flight mass spectrometry for identification of clinically pathogenic fungi

作　　者：王冲[1] 占萍[1] 刘维达[1] 

机构地区：[1]中国医学科学院北京协和医学院皮肤病研究所,南京210042

出　　处：《中国真菌学杂志》2013年第6期369-373,共5页Chinese Journal of Mycology

基　　金：卫生部临床学科重点项目(2010-2012);科技部重大专项子课题(2012ZX09301002005001005)

摘　　要：基质辅助激光解吸电离飞行时间质谱技术(MALDI-TOF-MS)目前是一种快速而可靠的微生物鉴定方法。随着可鉴定真菌谱的完善,MALDI-TOF MS技术已逐步应用于临床常见致病酵母菌、酵母样真菌和丝状菌的鉴定中,本文将就此做一综述。Matrix-assisted laser desorption ionization-time of flight mass spectrometry （MALDI-TOF MS）-based systems is a rapid and reliable method in identification of microorganism.With the improvement of identifiable fungal species spectrum,the application of MALDI-TOF MS systems have been introduced to identification of clinically pathogenic yeasts,yeast-like fungi,filamentous fungi and dermatophytes.

关 键 词：基质辅助激光解吸电离飞行时间质谱 真菌 鉴定 

分 类 号：R446.53[医药卫生—诊断学]