红花黄色素对犬心肌缺血及血流动力学的影响  

Effect of safflor yellow on myocardial ischemia and hemodynamics in dogs

作　　者：刘俐[1] 魏云[2] 卜振军 唐映红[1] 余望贻[1] 吴爱萍[2] 李燕飞[2] 

机构地区：[1]湖南中医药大学,湖南长沙410007 [2]湖南医药工业研究所,湖南长沙410014 [3]湖南九典制药有限公司,湖南长沙410011

出　　处：《中国医药科学》2013年第24期26-28,共3页China Medicine And Pharmacy

基　　金：湖南省科学技术厅科研条件创新专项(2013TT2010)

摘　　要：目的观察红花黄色素对犬急性心肌缺血以及血流动力学的影响。方法采用犬冠状动脉结扎心肌缺血动物模型,注射给予红花黄色素,观察其对心肌缺血程度、心肌缺血范围及心肌缺血梗死程度的影响,对血清肌酸激酶及血清乳酸脱氢酶的影响及对血流动力学的影响。结果红花黄色素能减轻心肌缺血程度,降低血清肌酸激酶及乳酸脱氢酶。增加冠脉流量,增加心输出量,对心肌耗氧量无明显影响。结论红花黄色素对犬心肌缺血梗塞具有明显的改善作用。Objective To evaluate effect of safflor yellow on acute myocardial ischemia and hemodynamics in dogs. Methods The model of myocardial ischemia was induced by ligating coronary artery in dogs. Safflor yellow was administered intravenously .The effects of safflor yellow on the extent and scope of myocardial ischemia,the extent of myocardial infarction,the levels of creatine kinase and lactic acid dehydrogenase in serum and the hemodynamics were examined. Results Safflor yellow could reduce the degree of myocardial ischemia,decrease the activity of creatine kinase and lactic acid dehydrogenase in serum,and increase the coronary flow and cardiac output in dogs.Myocardial oxygen consumption in dogs had no changes. Conclusion Safflor yellow could reduces remarkably the severity of myocardial infarction and improved hemodynamics in dogs.

关 键 词：红花黄色素 犬 心肌缺血 血流动力学 心肌耗氧量 

分 类 号：R285.5[医药卫生—中药学]