生殖免疫自身抗体检测在妇科不孕不育诊断中的临床价值评价  

Evaluation on clinical value of reproductive immune autoantibody determination in the diagnosis of gynecology infertility

作　　者：彭瑶[1] 黄红梅[1] 曾钦凤[1] 

机构地区：[1]广东省湛江市计划生育服务中心,广东湛江524000

出　　处：《中国医药科学》2013年第24期119-120,157,共3页China Medicine And Pharmacy

摘　　要：目的：对生殖免疫自身抗体检测在妇科不孕不育诊断中的临床价值进行评价与探讨。方法选取548例2011年8月～2012年7月在我院接受治疗的不孕不育患者，通过ELISA（酶联免疫吸附测定）对患者ACAb（抗心磷脂抗体）、AsAb（血清抗精子抗体）、TAAb（抗滋养层抗体）、EmAb（抗子宫内膜抗体）、AhAb（抗绒毛膜促性腺激素抗体）、ZPAb（抗透明带抗体）以及AOAb（抗卵巢抗体）等免疫生殖抗体进行测定。结果在AsAb、EmAb阳性患者中，自然流产组与原发不孕组进行比较，差异有统计学意义（P＜0.05）；在EmAb患者阳性中，对原发不孕组和继发不孕组进行比较，差异有统计学意义（P＜0.05）；在ACAb患者阳性中，阳性率最高的是继发不孕组,原发不孕组、自然流产组分别对比于继发不孕组，差异有统计学意义（P＜0.05）；AOAb患者阳性中，原发不孕组与自然流产组、继发不孕组进行对比，差异有统计学意义（P＜0.05）；TAAb与ZPAb患者阳性中，自然流产组、原发不孕组以及继发不孕组相比，差异有统计学意义（P＜0.05），AhAb患者阳性中，自然流产组、继发不孕组和原发不孕组相比，差异有统计学意义（P＜0.05）。548例患者中，抗体阳性患者所占比例为75.91%，而且7项中存在1项为阳性的患者所占比例为57.93%，存在2项的比例为31.92%，存在3项以上的比例为10.07%。结论在临床诊断女性不孕不育的措施中，对其进行生殖免疫自身抗体检测是非常有必要，值得临床应用与推广。Objective To evaluate and explore the clinical value of reproductive immune auto-antibody determination in the diagnosis of gynecology infertility. Methods 548 patients of gynecology infertility who were treated in our hospital during August 2011 to July 2012 were selected,and the patient＇s immune reproductive ant ibody（ACAb,AsAb,TAAb,EmAb,AhAb,ZPAb,AOAb,etc.）were detected by ELISA. Results In the positive AsAb and EmAb patients,the differences were significant between the spontaneous abortion group and primary infertility group（P 〈 0.05）; In the positive EmAb patients,the difference was significant between the primary infertility group and secondary infertility group（P〈0.05）;In the positive ACAb patients,the secondary infertility group had the highest positive rate, and the difference was significant between the primary infertility group or spontaneous abortion group and the secondary infertility group（P〈0.05）;In the positive AOAb patients,the difference was significant between the primary infertility group and the spontaneous abortion group or secondary infertility group（P 〈 0.05）;In the positive TAAb and ZPAb patients, the difference was significant between the spontaneous abortion group or primary infertility group and the secondary infertility group（P 〈 0.05）;In the positive AhAb patients,the difference was significant between the spontaneous abortion group or secondary infertility group and the primary infertility group（P 〈 0.05）;In 548 patients,the proportion of patients with positive antibodies was 75.91%, and the proportion of patients with the positive of only one item in seven items was 57.93%,that with the positive of two items was 31.92%, that with the positive of more than three items was 10.07%. Conclusion In clinical diagnosis measures of gynecology infertility,the reproductive immune auto-antibody determination is very necessary and worth to promote.

关 键 词：生殖免疫自身抗体检测 不孕不育 妇科 

分 类 号：R711.6[医药卫生—妇产科学]