化疗后T细胞亚群变化与乙型肝炎病毒再激活关系研究  

The relationship between T lymphocyte subsets and hepatitis B reactivation after chemotherapy

作　　者：庄见齐[1] 郑晓辉[1] 郑晓丹[2] 黄可青[1] 

机构地区：[1] 汕头大学医学院第一附属医院感染科, 广东省汕头515041 [2] 汕头市中心医院

出　　处：《中国基层医药》2014年第2期170-171,共2页Chinese Journal of Primary Medicine and Pharmacy

基　　金：广东省科技厅科研项目（2010B031600283）

摘　　要：目的 了解患者化疗后出现乙型肝炎病毒再激活时T细胞亚群CD3＋、CD4＋、CD8＋变化情况.方法 采用流式细胞术检测接受化疗的32例发生乙型肝炎病毒再激活和25例未发生乙型肝炎病毒再激活化疗前后外周血T细胞亚群.结果 化疗后CD3＋T细胞、CD4＋ T细胞百分比以及CD4＋/CD8＋较化疗前明显降低（P＜0.05）,CD8＋T细胞百分比较化疗前无明显变化（P＞0.05）.结论 化疗能对T细胞数量及比例产生明显的影响,抑制细胞免疫功能是导致乙型肝炎病毒再激活的原因之一.Objective To explore the changes ofT lymphocyte subsets CD3＋,CD4＋,CD8＋ in hepatitis B reactivation after chemotherapy.Methods Flow cytometry was used to detect T lymphocyte subsets of 32 patients with hepatitis B reactivation before and after chemotherapy.In addition,25 patients without hepatitis B reactivition were chosen as control group.Results After chemotherapy,the percentage of CD3＋ and CD4＋ T lymphocytes and the ratio of CD4＋/CDs＋ were significantly reduced than those before chemotherapy （P 〈 0.05）.However,the percentage of CD8＋ T lymphocytes was not significantly changed（P 〉 0.05）.Conclusion The chemotherapy can change the number and ratio of T lymphocyte subsets,the inhibition of the cellular immune function is one of the reason of hepatitis B virus reactivation.

关 键 词：化学治疗 T细胞亚群 乙型肝炎病毒 再激活 

分 类 号：R5[医药卫生—内科学]