硫酸吗啡缓释片联合注射用益气复脉(冻干)治疗中晚期肝癌疼痛的疗效观察  

Clinical observation of Morphine Sulfate Sustained-release Tablets combined with Yiqi Fumai Injection (freeze-dried) in treatment of advanced liver cancer pain

作　　者：顾宏韬[1] 

机构地区：[1]天津市中医药研究院附属医院肿瘤科,天津300120

出　　处：《现代药物与临床》2014年第1期52-54,共3页Drugs & Clinic

摘　　要：目的观察并评价硫酸吗啡缓释片联合注射用益气复脉(冻干)治疗中晚期肝癌疼痛的疗效。方法将80例伴有疼痛的中晚期肝癌患者随机分为治疗组(40例)和对照组(40例),对照组中度疼痛者口服硫酸吗啡缓释片60 mg,12 h一次,重度疼痛者口服硫酸吗啡缓释片90 mg,12 h一次;治疗组患者静脉滴注0.9%生理盐水250 mL+注射用益气复脉(冻干)3.9 g/次,1次/d,其他治疗同对照组患者,两组均治疗14 d,并在治疗前和治疗后对患者疼痛和生活质量进行评估。结果经过治疗,两组疼痛程度均较前减轻(P<0.05),生活质量QOL评分和KPS评分高于治疗前(P<0.05)。其中治疗组在疼痛程度VRS评分低于对照组(P<0.05),生活质量KPS和QOL评分治疗组均高于对照组(P<0.05)。不良反应发生率除便秘外治疗组明显低于对照组(P<0.01)。结论硫酸吗啡缓释片联合注射用益气复脉(冻干)治疗中晚期肝癌患者的疼痛疗效明显,能提高其生活质量,同时能减轻吗啡的不良反应。Objective To observe the clinical efficacy of Morphine Sulfate Sustained-release Tablets combined with Yiqi Fumai Injection （freeze-dried） in the treatment of advanced liver cancer pain. Methods Patients with advanced liver cancer pain （80 cases） were randomly divided into the treatment （40 cases） and control （40 cases） groups. In the control group, the patients with moderate and severe pain were po administered with Morphine Sulfate Sustained-release Tablets （60 and 90 mg, respectively）, 12 h/time. The patients in the treatment group were iv administered with Yiqi Fumai Injection （freeze-dried）, 3.9 g added into 250 mL physiological saline, once daily. The patients in the two groups were treated for 14 d. The pain and quality of life were evaluated before and after treatment. Results After treatment, the degree of pain in two groups were lower than that before treatment （P 〈 0.05）, and scores of QOL and KPS were higher than those before treatment （P 〈 0.05）. The pain score of VRS in the treatment group was lower than that in the control group （P 〈 0.05）, and scores of KPS and QOL in treatment group were higher than those in the control group （P 〈 0.05）. Incidence of adverse effect except constipation in the treatment group was significantly lower than that in the control group （P 〈 0.01）. Conclusion Morphine Sulfate Sustained-release Tablets combined with Yiqi Fumai Injection （freeze-dried） has an accurate curative effect on the advanced liver cancer pain, which could improve the quality of life and reduce the adverse effect of morphine.

关 键 词：硫酸吗啡缓释片 注射用益气复脉(冻干) 肝癌 疼痛评估 

分 类 号：R973[医药卫生—药品] R979.1[医药卫生—药学]