Overactive bladder symptom score to evaluate efficacy of solifenacin for the treatment of overactive bladder symptoms  

作　　者：Liu Ming Wang Jianye Yang Yong An Ruihua Wen Jianguo Guan Zhichen Zheng Shaobin Wang Dongwen Song Bo Liao Limin Guo Hongqian Xiao Jiaquan Sun Yinghao Shen Zhoujun Kong Chuize He Dalin Huang Yiran Wang Xiaofeng Zhang Xu Li Hanzhong Huang Jian Zhao Xiaokun Zeng Puqing Song Xishuang Ye Zhangqun 

机构地区：[1]Department of Urology, Beijing Hospital, Beijing 100730, China [2]Department of Urology, Beijing Chao-Yang Hospital, Beijing 100730, China [3]Department of Urology, The First Clinical College of Harbin Medical University, Harbin, Heilongiiang 150001, China [4]Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450003, China [5]Department of Urology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, China [6]Department of Urology, Nan Fang Hospital, Guangzhou, Guandong 440100, China [7]Department of Urology, The First Clinical College of Shanxi Medical University, Taiyuan, Shanxi 030012, China [8]Department of Urology, Southwest Hospital, Chongqing 400038, China [9]Department of Urology, China Rehabilitation Center, Beijing 100068, China [10]Department of Urology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, China [11]Department of Urology, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, China [12]Department of Urology, Changhai Hospital of Shanghai, Shanghai 200433, China [13]Department of Urology, Ruijin Hospital Affiliated to The Shanghai Jiaotong University Medical School, Shanghai 200025, China [14]Department of Urology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, China [15]Department of Urology, The First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China [16]Department of Urology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China [17]Department of Urology, Peking University People's Hospital, Beijing 100044, China [18]Department of Urology, The General Hospital of the People's Liberation Army, Beijing 100039, China [19]Department of Urology, Peking Union Medical College Hospital, Beijing 100005, China [20]Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510120, China [21]Department of Urology, Th

出　　处：《Chinese Medical Journal》2014年第2期261-265,共5页中华医学杂志（英文版）

摘　　要：Background Overactive bladder （OAB） is a series of symptoms with high prevalence in elderly people.This study was conducted using the overactive bladder symptom score （OABSS） to evaluate the efficacy of solifenacin succinate for the treatment of OAB.Methods This was a prospective,multicenter,single-arm,12-week study that enrolled 241 OAB patients.The patients received 5-10 mg/day solifenacin.Changes in OABSS,symptoms from voiding diary,perception of bladder condition （PPBC） score,international prostate symptom score （IPSS） and quality of life （QOL） were evaluated at weeks 0,4,and 12.The relationship between OABSS and PPBC score or parameters of voiding diary was also evaluated.Results At baseline,the mean OABSS for all patients was 9.41±2.40,and was reduced significantly at week 12 （-3.76 points; 61.21％,P ＜0.0001）.The OABSS subscore,PPBC score,IPSS,and QOL were also significantly reduced during the study （P ＜0.0001）.The overall incidence of adverse events was 19.91％ （44 cases）.The gastrointestinal system was the most commonly affected （11.31％）.Around 5.88％ of the cases had adverse events related to the genitourinary system.There was a strong correlation between OABSS and urinary symptoms that was recorded in the 3-day voiding dairy.Conclusions We showed that solifenacin was clinically effective for relieving OAB symptoms,considering the balance between efficacy,patients＇ well-being,and tolerability.OABSS integrates four OAB symptoms into a single score and can be a useful tool for research and clinical practice.Background Overactive bladder （OAB） is a series of symptoms with high prevalence in elderly people.This study was conducted using the overactive bladder symptom score （OABSS） to evaluate the efficacy of solifenacin succinate for the treatment of OAB.Methods This was a prospective,multicenter,single-arm,12-week study that enrolled 241 OAB patients.The patients received 5-10 mg/day solifenacin.Changes in OABSS,symptoms from voiding diary,perception of bladder condition （PPBC） score,international prostate symptom score （IPSS） and quality of life （QOL） were evaluated at weeks 0,4,and 12.The relationship between OABSS and PPBC score or parameters of voiding diary was also evaluated.Results At baseline,the mean OABSS for all patients was 9.41±2.40,and was reduced significantly at week 12 （-3.76 points; 61.21％,P ＜0.0001）.The OABSS subscore,PPBC score,IPSS,and QOL were also significantly reduced during the study （P ＜0.0001）.The overall incidence of adverse events was 19.91％ （44 cases）.The gastrointestinal system was the most commonly affected （11.31％）.Around 5.88％ of the cases had adverse events related to the genitourinary system.There was a strong correlation between OABSS and urinary symptoms that was recorded in the 3-day voiding dairy.Conclusions We showed that solifenacin was clinically effective for relieving OAB symptoms,considering the balance between efficacy,patients＇ well-being,and tolerability.OABSS integrates four OAB symptoms into a single score and can be a useful tool for research and clinical practice.

关 键 词：overactive bladder muscarinic antagonists symptom score 

分 类 号：R694[医药卫生—泌尿科学]