雄激素受体CAG重复多态性与BPH和PCa相关性的meta分析  

Correlation of androgen receptor CAG repeats with the risks of benign prostatic hyperplasia and prostate cancer: A meta-analysis

作　　者：王晓明[1] 孙亮[2] 张政[2] 史晓红[2] 张耀光[3] 魏东[3] 万奔[3] 杨泽[2] 王建业[1,3] 

机构地区：[1]北京协和医学院研究生院,北京100730 [2]卫生部北京老年医学研究所,北京100730 [3]卫生部北京医院泌尿外科,北京100730

出　　处：《中华男科学杂志》2014年第2期172-176,共5页National Journal of Andrology

基　　金：国家科技部十二五支撑计划(2012BAI10B01);国家自然科学基金(81241082);卫生部北京医院院内重大基金(BJ-2010-30)~~

摘　　要：目的:通过meta分析探讨雄激素受体(AR)基因CAG重复多态性与良性前列腺增生(BPH)和前列腺癌(PCa)发病风险的关系。方法:检索国内外大型数据库发表的AR基因CAG重复多态性与BPH和PCa相关性的文献,基于异质性检验的结果,分别采用M-H固定效应模型和随机效应模型合并比值比(OR)效应量,采用Begg和Egger偏倚分析评估本项meta分析的发表偏倚,系统评价AR基因CAG重复多态性与BPH和PCa发病风险的关系,并按种族进行分层分析。结果:检索获得文献29篇,最终纳入4篇符合条件的文献,累计BPH患者485例、PCa患者767例、正常对照组709例。BPH组和正常对照组间不存在异质性,M-H固定效应模型合并效应量后提示低CAG重复多态性与BPH无相关性。PCa组和BPH组及对照组间均存在异质性,随机效应模型提示低CAG重复多态性与PCa的风险呈正相关(OR PCa/对照=1.45,OR PCa/BPH=1.86,OR PCa/(BPH+对照)=1.66)。种族分层的亚组分析提示,低CAG重复多态性与PCa发病风险在种族间存在差异。Begg和Egger偏倚分析显示各组比较中均无显著发表偏倚。结论:AR受体低CAG重复多态性与PCa发病风险呈正相关,与BPH发病风险无相关性。Objective： To explore the association of the androgenic receptor （AR） CAG repeats with the risks of benign prostatic hyperplasia （BPH） and prostate cancer （PCa）. Methods： We searched the major databases at home and abroad for the literature addressing the correlation of the AR gene CAG repeats with BPH and PCa. Based on the results of heterogeneity tests, we used the M- H fixed effect model and random effect model to pool the odds ratio （OR） effect size. We evaluated publication bias by Begg and Egger bias analysis, investigated the association of CAG repeats with the risks of BPH and PCa by systematic review, and stratified their rela-tionship according to the races of the patients. Results ： Based on the selection criteria, 4 of the 29 identified studies were included, with 485 cases of BPH, 767 cases of PCa, and 709 controls. There was no heterogeneity between the BPH and control groups, and no correlation between short CAG repeats and BPH after pooling the odds ratio （OR） effect size. Heterogeneity was found among the BPH, PCa and control groups. Random effects model suggested an association of short CAG repeats with the risk of PCa （ ORPCa/contro = 1.45, ORPCa/BPH = 1.86, ORPCa/（BpH＋control） = 1.66）, while subgroup analysis with racial stratification indicated inter-ethnic differences between the two. Begg and Egger bias analysis showed no significant publication bias. Conclusion ： Shorter CAG repeats are positive- ly correlated with the risk of PCa but not with that of BPH.

关 键 词：雄激素受体 CAG多态性 良性前列腺增生 前列腺癌 

分 类 号：R697.3[医药卫生—泌尿科学]