运动管理对早期2型糖尿病血糖波动及胰岛功能的影响  

Effect of aerobic exercise training on glycemic variability and islet β cell function in type 2 diabetes in early stage

作　　者：苏桂蓉[1] 苏建彬[1] 王丽华[2] 赵丽华 徐峰[1] 高丹[1] 王晓华[1] 陈金锋[1] 金艳[1] 吴刚[1] 王雪琴[1] 

机构地区：[1]南通大学第二附属医院内分泌病科,江苏省226001 [2]南通大学第二附属医院护理部,江苏省226001

出　　处：《江苏医药》2014年第2期180-182,共3页Jiangsu Medical Journal

基　　金：南通市社会事业科技创新与示范计划项目(S11963;HS2012028);南通大学自然科学研究项目(2010Z082)

摘　　要：目的探讨以运动管理为中心的生活方式干预对早期2型糖尿病(T2DM)患者血糖波动及胰岛功能的影响。方法 60例糖化血红蛋白(HbA1c)<8.5%的早期T2DM患者(病程<1年),随机分为普通管理组(A组,30例)和运动管理组(B组,30例)。A组给予二甲双胍0.5g每日2次口服;B组执行规律的有氧运动锻炼。1年后评估动态血糖和相关指标。结果干预1年后,B组血糖波动及胰岛功能的改善优于A组(P<0.05)。结论运动管理为主的生活方式干预对早期T2DM患者血糖波动及胰岛功能具有明显改善作用。Objective To investigate the effect of aerobic exercise training on glycemic variability and islet cell function in type 2 diabetes mellitus（T2DM） in early stage. Methods Sixty early stage T2DM patients （diabetic duration 1 year and glycosylated hemoglobin〈 8. 5 %） were randomly assigned into two groups of A（treated with oral metformin 50 mg bid. ） and B（treated with aerobic exercise training）. The parameters of glycemic variability were calculated from the continuous glucose monitoring data. The islet cell function indices were derived from the OGTT. Result After treated for one year, the glycemic variability and islet cell function in group B were improved more than those in group A（P〈0. 05）. Conclusion The aerobic exercise training is an effective lifestyle intervention to improve the glycemic variability and islet cell function in T2DM patients in early stage.

关 键 词：有氧运动锻炼 2型糖尿病 

分 类 号：R589[医药卫生—内分泌]