双能量成像测量胃癌胃周脂肪组织碘含量判断浆膜受侵  

Measuring iodine concentration in perigastric adipose tissue with dual-energy CT for judgment of serosa invasion by gastric cancer

作　　者：杨丽[1] 时高峰[1] 吴润泽 李杨[1] 蔡晓嘉 

机构地区：[1]河北医科大学第四医院CT室,河北石家庄050011 [2]西门子医疗,北京100102

出　　处：《中国医学影像技术》2014年第2期250-254,共5页Chinese Journal of Medical Imaging Technology

基　　金：河北省高校强势特色学科资助项目(冀教高[2005]52号);河北省医学科学研究重点课题计划(20100126)

摘　　要：目的探讨应用双能量成像测量胃癌患者胃周脂肪组织碘含量判断浆膜受侵的价值。方法回顾性分析48例胃癌患者的术前双源CT双能量扫描图像,测量并比较双能量动脉期、静脉期浆膜受侵(n=32)与未受侵(n=16)胃周脂肪组织碘含量,采用ROC曲线法评价其判断胃癌浆膜受侵的能力。结果动脉期、静脉期浆膜受侵胃癌浆膜面脂肪组织碘含量均高于浆膜未受侵(动脉期:0.6mg/ml vs 0,Z=-4.24,P<0.001;静脉期:0.70mg/ml vs 0.30mg/ml,Z=-4.29,P<0.001)。动脉期曲线下面积(AUC)值为0.87,碘含量界值为0.25mg/ml时,敏感度为84.4%,特异度为81.2%;静脉期AUC值为0.88,碘含量界值为0.45mg/ml时,敏感度为87.5%,特异度为81.2%。结论应用双能量成像测量胃癌胃周脂肪组织碘含量能够较为准确地判断胃浆膜有无受侵。Objective To explore the value of measuring iodine concentration （IC） in perigastric adipose tissue with dual- energy CT （DECT） for judgment of serosa invasion by gastric cancer. Methods Totally 48 patients with gastric cancer who underwent preoperative DECT and surgery were enrolled. IC of perigastric adipose tissue was measured in invasion （n^32） and uninvaded group （n=16） at arterial phase （AP） and portal venous phase （PVP）, respectively. ROC curve was used to evaluate the capability of IC in detecting serosa invasion. Results IC was significantly higher in serosa invasion than in uninvaded patiernt （AP： 0.60 mg/ml vs 0, Z=--4.24, P^0. 001~ PVP： 0.7 mg/ml vs 0.3 mg/ml, Z=--4.29, P^0. 001）. With a threshold of 0.25 mg/ml at AP, area under curve （AUC）was 0.87, the sensitivity and specificity for detecting serosa invasion was 84.4% and 81.2%, respectively. With a threshold of 0.45 mg/ml at PVP, AUC was 0.88, the sensitivity and specificity was 87.5% and 81.20//00, respectively. Conclusion Measuring IC in perigastric adipose tissue with DECT is accurate for iudt^ment of serosa invasion in oatients with gastric cancer.

关 键 词：体层摄影术 X线计算机 碘定量 胃肿瘤 肿瘤分期 

分 类 号：R814.42[医药卫生—影像医学与核医学] R735.2[医药卫生—放射医学]