糖尿病患者非高密度脂蛋白胆固醇和载脂蛋白A-Ⅰ比值与冠状动脉病变程度的相关性  

Correlation between NHDL-C/apoA-Ⅰratio and severity of coronary artery disease in type 2 diabetic patients

作　　者：洪李锋[1,2] 罗松辉[1,2] 郭远林 蒋立新 李建军 

机构地区：[1]武汉市第五医院心内科 [2]江汉大学心血管病研究所,430050 [3]中国医学科学院国家心血管病中心 北京阜外医院血脂异常与心血管疾病诊治中心

出　　处：《中华老年心脑血管病杂志》2014年第2期120-123,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：中国高校博士点基金(20111106110013);首都临床特色应用研究(Z121107001012015)

摘　　要：目的 探讨非HDL-C（NHDL-C）/载脂蛋白A-Ⅰ （apoA-Ⅰ）比值与2型糖尿病患者冠状动脉病变严重程度的相关性.方法 选择因劳力性胸痛而行冠状动脉造影的2型糖尿病患者373例,依据Gensini评分三分位分为3组,低分组＜8分（143例）;中分组8～28分（109例）;高分组＞28分（121例）,评价NHDL-C/apoA-Ⅰ比值与冠状动脉病变严重程度的相关性.结果 3组患者HDL-C、脂蛋白（a）、apoB、NHDL-C、NHDL-C/apoA-Ⅰ比值等比较,差异有统计学意义（P＜0.05,P＜0.01）;Pearson相关分析和Spearman相关分析均显示,2型糖尿病患者NHDL-C/apo-A-Ⅰ比值与Gensini评分呈正相关（r=0.146,P＜0.01;r=0.127,P＜0.05）.多元线性回归分析显示,2型糖尿病患者NHDL-C/apoA-Ⅰ比值与冠状动脉病变严重程度独立相关（偏相关回归系数=3.361,P＜0.05）.结论 NHDL-C/apoA-Ⅰ与2型糖尿病患者冠状动脉病变严重程度独立相关.Objective To study the correlation between NHDL-C/apoA-Ⅰ ratio and severity of coronary artery disease in type 2 diabetic patients.Methods Three hundred and seventy-three type 2 diabetic patients who underwent coronary angiography were divided into low Gensini score group （n=143）,intermediate Gensini score group（n=109）,and high Gensini score group （n =121）.The correlation between NHDL-C/apoA-Ⅰ ratio and severity of coronary artery disease was assessed.Results The serum levels of HDL-C,lipoprotein （a）,apoB,NHDL-C,NHDL-C/apoA-Ⅰ were significantly different in the 3 groups （P＜0.05,P＜0.01）.Pearson and Spearman correlation analysis showed that the NHDL-C/apoA-Ⅰ ratio was correlated with the Gensini score in type 2 diabetic patients （r=0.146,P＜0.01 ; r=0.127,P＜0.05）.Multivariate linear regression analysis displayed that the NHDL-C/apoA-Ⅰ ratio was independently correlated with the severity of coronary artery disease in type 2 diabetic patients （partial correlation regression coefficient=3.361,P＜0.05）.Conclusion The NHDL-C/apoA-Ⅰ ratio is independently correlated with the severity of coronary artery disease in type 2 diabetic patients.

关 键 词：糖尿病 胆固醇 HDL 载脂蛋白A-Ⅰ 冠状血管造影术 冠状动脉疾病 胸痛 

分 类 号：R541.4[医药卫生—心血管疾病]