颈动脉粥样硬化斑块成分与性别的相关性研究  

Incidence of carotid atherosclerotic plaques in male and female patients

作　　者：马露[1] 崔豹[1] 韩旭[1] 马林[1] 蔡幼铨[1] 蔡剑鸣[1] 

机构地区：[1]解放军总医院放射诊断科,北京100853

出　　处：《中华老年心脑血管病杂志》2014年第2期171-173,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金："十二五"全军科研计划面上项目(CWS11J065)

摘　　要：目的探讨颈动脉粥样硬化患者斑块成分的性别差异。方法选取进行颈动脉3.0T MR高分辨扫描的颈动脉粥样硬化斑块患者154例,男性95例,女性59例,根据MR扫描结果,对斑块成分和性质进行分析,比较男、女性的斑块成分差异。结果男性斑块内富脂质坏死核(42.1%vs 20.0%,P=0.005)和薄或破裂纤维帽(59.7%vs39.5%,P=0.046)的发生率明显高于女性;女性斑块内钙化的发生率有高于男性的趋势(74.6%vs 65.3%,P=0.225),男性与女性斑块内出血发生率比较,差异无统计学意义(24.2%vs 22.0%,P=0.756)。结论颈动脉粥样硬化斑块患者中,男性不稳定斑块的发生率高于女性,这可能有助于解释脑卒中发病率的性别差异。Objective To study the incidence of carotid atherosclerotic plaques in male and female patients.Methods One hundred and fifty-four patients with carotid atherosclerotic plaques （95 males and 59 females） who underwent 3.0T MR carotid high-resolution scanning were included in this study.The plaques in male and female patients were analyzed and compared.Results The incidence of lipid-rich necrotic core and thin/ruptured fibrous cap was significantly higher in male patients than in female patients （42.1％ vs 20.0％,P=0.005） whereas the incidence of calcified plaques was significantly higher in female patients than in male patients （59.7％ vs 39.5％,P=0.046）.No significant difference was found in intraplaque hemorrhage between male and female patients.Conclusion The incidence of unstable plaques is higher in male carotid atherosclerotic plaque patients than in female carotid atherosclerotic plaque patients,which may help explain the different incidences of ischemic stroke in male and female patients.

关 键 词：颈动脉狭窄 动脉粥样硬化 磁共振成像 性别因素 

分 类 号：R445.1[医药卫生—影像医学与核医学]