Direct N-gem-difluorocyclopropylation of nitro-heterocycles by utilizing gem-difluorocyclopropyl tosylate  

作　　者：Wei-Peng Gu Jin-Hong Lin Ji-Chang Xiao 

机构地区：[1]Key Laboratory of Organofluorine Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences

出　　处：《Chinese Chemical Letters》2014年第1期24-28,共5页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(Nos.21032006,21172240);the 973 Program of China(No.2012CBA01200);the Chinese Academy of Sciences forfinancial support

摘　　要：We have developed an efficient method to achieve N-gem-difluorocyclopropylation of N-heterocycles with the use of gem-difluorocyclopropyl tosylate as a building block under mild conditions, gem- Difluorocyclopropyl tosylates could be easily prepared on a large scale and exhibit great stability.We have developed an efficient method to achieve N-gem-difluorocyclopropylation of N-heterocycles with the use of gem-difluorocyclopropyl tosylate as a building block under mild conditions, gem- Difluorocyclopropyl tosylates could be easily prepared on a large scale and exhibit great stability.

关 键 词：N-gem-Difluorocyclopropylation N-Heterocycles gem-Difluoracyclopropyl tosylate Building block 

分 类 号：O626[理学—有机化学]