A simple and efficient approach to one-pot synthesis of mono- and bis-N-aryl-3-aminodihydropyrrol-2-one-4-carboxylates catalyzed by InCl_3  

作　　者：Seyed Sajad Sajadikhah Malek Taher Maghsoodlou Nourallah Hazeri 

机构地区：[1]Department of Chemistry,Payame Noor University,Iran [2]Department of Chemistry,Faculty of Sciences,University of Sistan and Baluchestan

出　　处：《Chinese Chemical Letters》2014年第1期58-60,共3页中国化学快报（英文版）

基　　金：support from the Research Council of University of Sistan and Baluchestan and Payame Noor University

摘　　要：An efficient and straightforward procedure has been developed for the synthesis of highly substituted mono- and bis-N-aryl-3-aminodihydropyrrol-2-one-4-carboxylates via a one-pot, four-component domino reaction of amines, dialkyl acetylenedicarboxylates and formaldehyde in the presence of InCl3 （20 mol%） in MeOH at ambient temperature. The salient advantages of this method are mild reaction conditions, environmentally benign, high to excellent yields, shorter reaction times, easy operation and no column chromatographic separation.An efficient and straightforward procedure has been developed for the synthesis of highly substituted mono- and bis-N-aryl-3-aminodihydropyrrol-2-one-4-carboxylates via a one-pot, four-component domino reaction of amines, dialkyl acetylenedicarboxylates and formaldehyde in the presence of InCl3 （20 mol%） in MeOH at ambient temperature. The salient advantages of this method are mild reaction conditions, environmentally benign, high to excellent yields, shorter reaction times, easy operation and no column chromatographic separation.

关 键 词：Dihydropyrrol-2-one Heterocycle InCl3 Four-component reaction 

分 类 号：O621.36[理学—有机化学]