Synthesis and bioactivity of novel strobilurin derivatives containing the pyrrolidine-2,4-dione moiety  

作　　者：Gui-Hua Lu Hai-Bin Chu Min Chen Chun-Long Yang 

机构地区：[1]Jiangsu Key Laboratory of Pesticide Science,Nanjing Agricultural University [2]College of Science,Nanjing Agricultural University [3]Key Laboratory of Monitoring and Management of Crop Diseases and Pest Insects,Ministry of Agriculture,Nanjing Agricultural University

出　　处：《Chinese Chemical Letters》2014年第1期61-64,共4页中国化学快报（英文版）

基　　金：supported by the National Key Technologies R&D Program of China(No.2011BAE06B04);Science&Technology Pillar Program of Jiangsu Province(No.BE2012371);the National Natural Science Foundation of China(No.31171889);863 Program of China(No.2011AA10A206);the Fundamental Research Funds for the Central Universities of China(No.KYZ201223)

摘　　要：（E）-Methyl-2-（2-（bromomethyl）phenyl）-3-methoxyacrylate was reacted with substituted 1-acetylpyr-rolidine-2,4-diones and 3-（1-（hydroxylamino）ethylidene）pyrrolidine-2,4-diones respectively to synthesize two series of/%methoxyacrylate derivatives containing the pyrrolidine-2,4-dione moiety. The structures of the targeted compounds were confirmed by IR, 1H NMR, 13C NMR, MS and elemental analysis. The fungicidal activity against Rhizoctonia solani, Botrytis cinerea and Fusarium graminearum was evaluated. The bioassay results demonstrated that these compounds showed visible fungicidal activity.（E）-Methyl-2-（2-（bromomethyl）phenyl）-3-methoxyacrylate was reacted with substituted 1-acetylpyr-rolidine-2,4-diones and 3-（1-（hydroxylamino）ethylidene）pyrrolidine-2,4-diones respectively to synthesize two series of/%methoxyacrylate derivatives containing the pyrrolidine-2,4-dione moiety. The structures of the targeted compounds were confirmed by IR, 1H NMR, 13C NMR, MS and elemental analysis. The fungicidal activity against Rhizoctonia solani, Botrytis cinerea and Fusarium graminearum was evaluated. The bioassay results demonstrated that these compounds showed visible fungicidal activity.

关 键 词：Strobilurin Pyrrolidine-2 4-dione Synthesis Fungicidal activity 

分 类 号：O621.2[理学—有机化学]