Synthesis and acaricidal activity of strobilurin-pyrimidine derivatives  

作　　者：Bao-Shan Chai Chang-Ling Liu Hui-Chao Li Shao-Wu Liu Ying Xu Yu-Quan Song Jun-Biao Chang 

机构地区：[1]College of Chemistry and Molecular Engineering,Zhengzhou University [2]State Key Laboratory of the Discovery and Development of Novel Pesticide,Shenyang Research Institute of Chemical Industry Co.,Ltd.

出　　处：《Chinese Chemical Letters》2014年第1期137-140,共4页中国化学快报（英文版）

基　　金：the Outstanding Young Scholarship from the National Natural Science Foundation of China(No.30825043);NSFC(No.21172202);the Outstanding Scholar Foundation of Henan Province(No.094100510019)for financial support;supported by the National Key Basic Research Program of China(973 Program)(Nos.2010CB126105 and 2012CB724501);the National Key Technology Support Program during the 12th Five-Year Plan Period(Nos.2011BAE06B00,2011BAE06B01,2011BAE06B02,2011BAE06B03 and 2011BAE06B05)

摘　　要：Pyriminostrobin, a new acaricide, was discovered in our previous studies. Because introducing fluorine into organic compounds can increase bioactivity, pyriminostrobin was modified as a series of strobilurin-pyrimidine derivatives for biological screening. The compounds were characterized by 1H NMR, MS and elemental analysis. Preliminary bioassays demonstrated that compounds 7e and 7i exhibited significant control against Tetranychus cinnabarinus （Boisd.） at 0.625 mg L^-1, and their acaricidal potencies were higher than pyriminostrobin in a greenhouse. The relationship between structure and acaricidal activity was also studied.Pyriminostrobin, a new acaricide, was discovered in our previous studies. Because introducing fluorine into organic compounds can increase bioactivity, pyriminostrobin was modified as a series of strobilurin-pyrimidine derivatives for biological screening. The compounds were characterized by 1H NMR, MS and elemental analysis. Preliminary bioassays demonstrated that compounds 7e and 7i exhibited significant control against Tetranychus cinnabarinus （Boisd.） at 0.625 mg L^-1, and their acaricidal potencies were higher than pyriminostrobin in a greenhouse. The relationship between structure and acaricidal activity was also studied.

关 键 词：Strobilurin-pyrimidine Acaricidal activity Intermediate derivatization method Pyriminostrohin 

分 类 号：TQ454.2[化学工程—农药化工]