Solvent-free synthesis of substituted thiopyrans via multicomponent reactions of α-haloketones  

作　　者：Fatemeh Sheikholeslami-Farahani Zinatossadat Hossaini Faramarz Rostami-Charati 

机构地区：[1]Department of Chemistry,Firoozkooh Branch,Islamic Azad University,Firoozkooh,Iran [2]Department of Chemistry,Qaemshahr Branch,Islamic Azad University,Qaemshahr,Iran [3]Department of Chemistry,Facualty of Science,Gonbad Kavous University,Gonbad,Iran

出　　处：《Chinese Chemical Letters》2014年第1期152-154,共3页中国化学快报（英文版）

摘　　要：A straightforward and efficient method for the synthesis of thiopyran derivatives via three-component reaction of alkyl propiolate, benzoylisothiocyanate or its derivatives and α-haloketones in the presence of triphenylphosphine under solvent-free conditions at 70℃ without using any catalyst is reported, The method offers several advantages including high yields of products and an easy work-up procedure.A straightforward and efficient method for the synthesis of thiopyran derivatives via three-component reaction of alkyl propiolate, benzoylisothiocyanate or its derivatives and α-haloketones in the presence of triphenylphosphine under solvent-free conditions at 70℃ without using any catalyst is reported, The method offers several advantages including high yields of products and an easy work-up procedure.

关 键 词：Thiopyran Triphenylphosphine α-Haloketones Solvent-free conditions Benzoyl isothiocyanate 

分 类 号：O623.55[理学—有机化学]