Sodium fluoride as an efficient catalyst for the synthesis of 2,4-disubstituted-1,3-thiazoles and selenazoles at ambient temperature  

作　　者：Janardhan Banothu Krishnaiah Vaarla Rajitha Bavantula Peter A.Crooks 

机构地区：[1]Department of Chemistry,National Institute of Technology [2]Department of Pharmaceutical Sciences,College of Pharmacy,University of Arkansas for Medical Sciences

出　　处：《Chinese Chemical Letters》2014年第1期172-175,共4页中国化学快报（英文版）

基　　金：the Ministry of Human Resource Development for their support

摘　　要：Sodium fluoride was found to be a simple, mild and efficient catalyst for the synthesis of 2,4- disuhstituted 1,3-thiazoles and selenazoles utilizing phenacyl bromides/3-（2-bromoacetyl）-2H-chro- men-2-one and thioureaJphenylthiourea/selenourea in aqueous methanol at ambient temperature. Analytically pure products are formed within 1-3 rain in excellent yields.Sodium fluoride was found to be a simple, mild and efficient catalyst for the synthesis of 2,4- disuhstituted 1,3-thiazoles and selenazoles utilizing phenacyl bromides/3-（2-bromoacetyl）-2H-chro- men-2-one and thioureaJphenylthiourea/selenourea in aqueous methanol at ambient temperature. Analytically pure products are formed within 1-3 rain in excellent yields.

关 键 词：Sodium fluoride1 3-Thiazoles Selenazoles Aqueous methanol Ambient temperature 

分 类 号：O626.25[理学—有机化学]