良性前列腺增生与尿白蛋白排泄量的关系  

Relationship between benign prostatic hyperplasia and urine albumin excretion

作　　者：王庭俊[1] 陈纯娴[1] 王中心[1] 

机构地区：[1]福建医科大学附属第一医院干部科福建省高血压病研究所,福州350005

出　　处：《中华老年医学杂志》2014年第2期179-182,共4页Chinese Journal of Geriatrics

摘　　要：目的探讨良性前列腺增生（BPH）与尿白蛋白排泄量的关系。方法人选60～70岁的男性住院患者258例，询问病史，根据超声测定的前列腺体积（PV）分为BPH组（PV≥20m1）和非良性前列腺增生（NBPH）组（PV〈20m1），检测两组患者尿白蛋白及尿肌酐，并计算尿白蛋白／肌酐（UACR）；检测空腹血糖及空腹胰岛素，计算胰岛素抵抗指数（HOMA-IR）。采用Pearson相关分析PV与其他指标的相关性，采用多因素Logistic回归分析患BPH的相关因素。结果BPH组的uACR高于NBPH组[（163．6±69．8）mg／g比（73．3±55．6）mg／g，t=4．81，P〈0．01]，BPH组较NBPH组的高血压病程长[（9．2±6．6）年比（6．0±3．6）年，t=2．27，P〈0．051。随着尿白蛋白排泄量的增加，BPH的患病率增加（X2=4．58，P〈0．05），PV增大（F=4．85，P〈0．01）。Pearson相关分析结果显示，PV与UACR、HOMA—IR、高血压病程、体质指数呈正相关（r=0．248、0．229、0．183、0．157，均P〈0．05）。多因素Logistic回归分析显示UACR、HOMA—IR、高血压病程是影响BPH患病的相关因素（OR=16．348、1．040、0．166，均P〈0．05）。结论BPH与UACR存在相关性，提示动脉粥样硬化与BPH存在密切关系，胰岛素抵抗可能在两者的发生发展中起着重要的作用。Objective To investigate the （BPH） and urine albumin excretion. Methods relationship between benign prostatic hyperplasia A total of 258 male inpatients aged 60 to 70 years were enrolled in this study. According to prostate volume （PV） measured by transrectal ultrasonography, patients were divided into BPH group（ PV≥20 ml） and NBPH（non benign prostatic hyperplasia ） group（PV〈20 mI）. Urine albumin and urine creatinine concentrations were measured and urine albumin/creatinine ratio（UACR） was calculated. Fasting blood glucose （FBG） and fasting insulin（FINS） also were measured, insulin resistance index（HOMA-IR） was calculated based on the formula HOMA-IR--ln（FBG X FINS/22.5）. The correlation between PV and other indicators were analyzed by Pearson correlation analysis. The risk factors for BPH were analyzed by logistic regression analysis. Results UACR was significantly higher in BPH group than in NBPH group[（163.6± 69.8）mg/g vs. （73.3±55.6）mg/g, t=4.81, P〈0.01],and hypertension duration was longer in BPH group than in NBPH group [（9.2±6.6）years vs. （6.0±3.6）years,t=2.27, P〈0. 051. The prevalence rate of BPH and PV were increased along with increasing of urine albumin excretion（X2 = 4.58, F= 4.85, respectively, P〈0.05 or 0.01）. Prostate volume was positively correlated with UACR, HOMA-IR, hypertension duration, body mass index（r=0.248, 0.229, 0.183, 0.157, respectively, all P〈 0.05）. Logistic regression analysis indicated that UACR, HOMA-IR and hypertension duration were the risk factors for BPH（OR=16. 348, 1. 040, 0. 166, respectively, all P d0.05）. Conclusions BPH is correlated with UACR, which indicates that there is a close relationship between atheroselerosis and BPH. Insulin resistance probably plays an important role in the Drouression of arteriosclerosis and BPH.

关 键 词：前列腺增生 白蛋白尿 

分 类 号：R697.3[医药卫生—泌尿科学]