成纤维细胞激活蛋白α与肿瘤的研究进展  

Research Progress of Fibroblast Activation Protein α and Tumor

作　　者：陈渊[1] 郑伟明[1] 

机构地区：[1]温州医学院附属第一医院神经外科,浙江温州325000

出　　处：《医学综述》2014年第2期247-250,共4页Medical Recapitulate

摘　　要：成纤维细胞激活蛋白α(FAP-α)是一个Ⅱ型穿膜蛋白,属于丝氨酸蛋白酶家族,具有二肽基肽酶和胶原酶活性。FAP-α在肿瘤的生长、浸润、转移中发挥重要作用。其限制性的表达于肿瘤、纤维变性、创伤、关节炎等病理部位,而在大多数正常组织中不表达,大多数由病理部位激活的成纤维细胞表达,故以FAP-α作为肿瘤基质标志物的靶向治疗将成为可能。Fibroblast activation protein alpha （ FAP-α ） is a type II integral membrane protein that belongs to the serine protease family, with a dipeptidyl peptidase and collagenase activity. FAP-α plays an important role in tumor growth, invasion and metastasis. It is limitedly exprcsse in pathologic sites, including cancer,fibrosis, arthritis, wounding, but not expressed in most normal tissues. The majority of FAP-ais expressed by activated fibroblasts responding to the pathologic situations,therefore as the tumor stmma marker, FAP-α targeted therapy will become possible.

关 键 词：成纤维细胞激活蛋白α 靶向治疗 肿瘤相关成纤维细胞 肿瘤微环境 

分 类 号：R73[医药卫生—肿瘤]