双波长紫外分光光度法测定复方氧氟沙星喷雾剂中盐酸达克罗宁和氧氟沙星的含量  

Determination of dydonine hydrochloride and foloxacin in compound oflosacin spray by dual-wavelength spactrophotometry

作　　者：潘张鹏 章如玲 

机构地区：[1]浙江省瑞安市中医院药剂科,瑞安325200

出　　处：《海峡药学》2014年第1期79-80,共2页Strait Pharmaceutical Journal

摘　　要：目的 建立双波长紫外分光光度法测定复方氧氟沙星喷雾剂中盐酸达克罗宁和氧氟沙星的含量.方法 盐酸达克罗宁以282nm为测定波长,300.7nm为参比波长;氧氟沙星以225nm测定其波长.结果 盐酸达克罗宁在3.0054～8.0114μg·mL-1范围内线性关系良好,相关系数r=0.9994,平均回收率100.8%,RSD=0.97%;氧氟沙星在1.4973～3.9928μg·mL-1范围内相关系数良好,r=0.9992,平均回收率为100.4%,RSD=0.92%.结论 该方法简便,结果准确,适用于复方氧氟沙星喷雾剂中盐酸达克罗宁和氧氟沙星的含量测定.OBJECTIVE To establish a accurate method for the determination of Clomipramine Dyclonine and ofloxacin in compound ofloxacin spray. METHODS A dual-wavelength spectrophotometry method was used for the determination of Clomipramine Dyclonine and ultroviolet spectrophotometry method for ofloxacin. RESULTS The average recoveries and relative standard deviations were 100. 8% ,0. 97% for Clomipramine Dyclonine and 100. 4% , 0.92% for ofloxacin. CONCLUSION The method is simple and accurate and can he used for the quality control of compound ofloxacin spray.

关 键 词：双波长紫外分光光度法 喷雾剂 氧氟沙星 盐酸达克罗宁 

分 类 号：R927.2[医药卫生—药学]