窄谱抗菌药联合双黄连注射液治疗老年肺部感染效果观察  

Therapy effect of narrow-spectrum antibiotic combined with Shuanghuanglian on secondary pulmonary fungal infection in elderly patients with chronic disease

作　　者：唐京京 陈石桂[2] 

机构地区：[1]桂林市博爱医院,广西桂林541000 [2]桂林医学院附属医院

出　　处：《山东医药》2014年第6期35-37,共3页Shandong Medical Journal

基　　金：广西壮族自治区卫生厅自筹经费科研课题(Z2013444)

摘　　要：目的观察敏感窄谱抗菌药联合双黄连注射液治疗老年肺部感染患者的临床疗效。方法将90例老年肺部感染患者采用随机数字法分为小剂量窄谱抗菌药联合双黄连注射液组(A组)、大剂量窄谱抗菌药联合双黄连注射液组(B组)、广谱抗菌药联合双黄连注射液组(C组),每组各30例,对比治疗后第10天时患者肺部感染疗效、肺部真菌感染例数、真菌耐药发生率及平均住院时间。结果治疗第10天A组肺部感染疗效优于B组、C组(P<0.05)。治疗后第10天A组继发肺部真菌感染例数少于B组、C组(P<0.05)。治疗后第10天A组耐药例数少于C组(P<0.05)。A组平均住院时间少于B组、C组(P<0.05)。结论小剂量敏感窄谱抗菌药联合双黄连注射液治疗老年肺部感染疗效较好,可减少继发肺部真菌感染的发生率,缩短住院时间。Objective To investigate the therapy effect of narrow-spectrum antibiotic combined with Shuanghuanglian （SHL） on secondary pulmonary fungal infection in the elderly patients with chronic disease,and then to provide preventive measures and foundation.Methods Ninety cases of elderly patients with chronic disease were randomly divided into three groups：group A,low doses of narrow spectrum antibiotic with SHL; group B,high doses of narrow-spectrum antibiotic with SHL,and group C,broad-spectrum antibiotic with SHL.Then we observed and compared the statistics on the tenth day of therapy of the three groups about fungal infection cases as well as efficacy of the therapy on the tenth day,and the average duration of hospitalization and the drug resistance.Results On the tenth day of therapy,the cases of secondary pulmonary fungal infection in the group A were less than those in the group B and group C （P ＜ 0.05）.On the tenth day,the cases of drug resistance in the three groups were respectively：0,3 and 7 and the cases in the group A were less than that in the group C （P ＜ 0.05）.On the tenth day,the efficacy of group A was better than that in the other two groups （P ＜ 0.05）.Finally,the average duration of hospitalization of group A was less than that of the other two groups （P ＜ 0.05）.Conclusion Low doses of narrow spectrum antibiotic with SHL can shorten the hospital stays,reduce the production of drug-resistant strains and prevent secondary pulmonary fungal infection effectively.

关 键 词：抗菌药 双黄连 慢性病 肺部感染 真菌 

分 类 号：R563.1[医药卫生—呼吸系统]