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作 者:黄志辉[1] 甘继宏[1] 王巍[1] 蒋银花[2] 魏雅娜[1] 沈倩波[1]
机构地区:[1] 兰州军区乌鲁木齐总医院心内科,新疆 乌鲁木齐830000 [2] 兰州军区乌鲁木齐总医院超声科,新疆 乌鲁木齐830000
出 处:《医学临床研究》2014年第1期18-20,共3页Journal of Clinical Research
基 金:全军医药卫生科研基本课题(课题编号:CWS10JA24)
摘 要:[目的]评价右心室不同起搏方式对心衰犬心功能及心室同步的影响。[方法]12只心衰犬,采用自身对照方法随机行右房-右室心尖部(RVA)、右房-右室流出道间隔部(RVS)、右房-右室双部位(RV-Bi)、右房-双室(Bi-V )起搏,起搏频率180次/分钟,每种方式起搏前及起搏稳定15 min后行彩色多普勒超声心动图检查,测定左心室舒张末期直径(LVEDd)、左室射血分数(LVEF)、室间机械延迟(IVMD)、室间隔与左室后壁运动延迟(SPWMD)、左心室12个节段达峰时间的标准差(Ts-SD )。[结果]与起搏前及 RVA起搏相比,RVS、RV-Bi、Bi-V 起搏时的 LVEDd、IVMD、SPWMD、Ts-SD减小,LVEF增加,其差异有显著性( P <0.05);与RVS起搏相比,RV-Bi及Bi-V起搏时的LVEDd、IVMD、SPWMD、Ts-SD减小,LVEF增加,其差异有显著性( P <0.05);与 Bi-V 起搏相比,RV-Bi起搏时的 SPWMD、Ts-SD增加,其差异有显著性( P <0.05),而LVEDd、IVMD、LVEF差异无显著性( P >0.05)。[结论]对心衰犬,RV-Bi起搏疗效明显,可作为心脏再同步化治疗(CRT )的备选模式,RVS起搏有效但疗效欠佳,RVA起搏则无效。[Objective] To evaluate the efficacy of different right ventricular pacing modes for the treat-ment of heart failure .[Methods]Self control method was used .Twelve dogs with heart failure randomly re-ceived right atrium-right ventricular apex (RVA) ,right atrium-right ventricular septal(RVS) ,right atrium-right ventricular bifocal(RV-Bi) and biventricular(Bi-V) pacing ,respectively .The pacing frequency was 180 times per minute .Color Doppler echocardiography was performed before and 15min after pacing .Left ventric-ular end-diastolic diameter(LVEDd) ,left ventricular ejection fraction(LVEF) ,interventricular mechanical de-lay(IVMD) ,interventricular septum and left ventricular posterior wall motion delay (SPWMD) and left ven-tricular 12-segment peak time standard deviation(Ts-SD) were measured .[Results]Compared with before pa-cing and RVA pacing ,LVEDd ,IVMD ,SPWMD and Ts-SD decreased and LVEF increased in RVS ,RV-Bi and Bi-V pacing ,and there was significant difference ( P 〈 0 .05) .Compared with RVS pacing ,LVEDd , IVMD ,SPWMD and Ts-SD decreased and LVEF increased in RV-Bi and Bi-V pacing ,and there was signifi-cant difference( P〈0 .05) .Compared with Bi-V pacing ,SPWMD and Ts-SD increased in RV-Bi pacing ,and there was significant difference( P 〈0 .05) .There was no significant difference in LVEDd ,IVMD and LVEF ( P〈0 .05) .[Conclusion]RV-Bi pacing for the treatment of heart failure has obvious efficacy ,and can be used as an alternative mode for cardiac resynchronization therapy (CRT ) .RVS pacing is effective but has poor effi-cacy .RVA pacing is ineffective .
分 类 号:R541.61[医药卫生—心血管疾病]
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