泌乳分子机制及基因调控网络  

Molecular Mechanism of Lactation and Gene Regulation Networks

作　　者：任洪辉 王永[1] 江明锋[1,2] 

机构地区：[1]动物遗传育种学国家民委一教育部重点实验室,成都610041 [2]西南民族大学生命科学与技术学院,成都610041

出　　处：《生物技术通报》2014年第1期39-45,共7页Biotechnology Bulletin

基　　金：国家自然科学基金项目(31172198);国家科技支撑计划课题(2012BAD13B06);四川省青年科技基金(09ZQ026-011);教育部科学技术研究重点项目(201265);中央高校科研项目(12ZYXS74)

摘　　要：为了提高泌乳家畜的产奶性能,使得进一步理解乳腺的功能及其调控机制变得十分必要。早期的研究倾向于从组织学和激素层面研究分析乳腺的生理功能,随着近年来分子生物学技术的发展,芯片等高通量技术被应用到乳腺泌乳机制的研究中,泌乳生物学进入了一个全新的发展时期。综述了近年来国内外关于乳腺泌乳机制方面的研究进展,如乳腺各个泌乳时期的基因调控网络、乳汁主要成分的合成调控网络、参与乳腺泌乳周期循环的信号传导通路等。In order to improve the production performance of animals, that understand better the function and regulation mechanisms of the mammary gland become very necessory. Early studies tended to analyze the physiological function of mammary gland from histology and hormone levels. With the development of molecular biology techniques, high-throughput technologies such as gene chip to study mammary gland and lactation biology has entered a new stage of development. In this review, we presented several aspects in molecular biology of lactation biology, such as gene networks about each stage were revealed, synthetic regulation network about the main composition of milk, signaling pathways involved in mammary gland lactation cycle.

关 键 词：乳腺 泌乳 分子机制 调控网络 信号通路 

分 类 号：S852[农业科学—基础兽医学]